Iron-modulated virulence factors of Entamoeba histolytica

被引：8

作者：

Gastelum-Martinez, Aurora ^{[1
]}

Leon-Sicairos, Claudia ^{[1
]}

Plata-Guzman, Laura ^{[1
]}

Soto-Castro, Liliana ^{[1
]}

Leon-Sicairos, Nidia ^{[2
,3
]}

de la Garza, Mireya ^{[4
]}

机构：

[1] Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Programa Reg Noroeste El Posgrad Biotecnol, Ave Amer & Josefa Ortiz,Cd Univ, Culiacan 80030, Sinaloa, Mexico

[2] Univ Autonoma Sinaloa, CIASaP Fac Med, Cedros & Sauces Frac Fresnos, Culiacan 80246, Sinaloa, Mexico

[3] Hosp Pediat Sinaloa, Dept Invest, Blvd Constituc S-N, Culiacan 80200, Sinaloa, Mexico

[4] Ctr Invest & Estudios Avanzados IPN CINVESTAV IPN, Dept Biol Celular, Ave Inst Politecn Nacl 2508, Cdmx 07360, Mexico

来源：

FUTURE MICROBIOLOGY | 2018年 / 13卷 / 11期

关键词：

binding proteins; cysteine proteases; Entamoeba histolytica; hemoglobinase; IREs; IRPs; iron; oxidation-reduction proteins; virulence factors; virulence; D-PHOSPHOGLYCERATE DEHYDROGENASE; HOST-PATHOGEN INTERACTIONS; CYSTEINE PROTEINASE; BIOCHEMICAL-CHARACTERIZATION; PROTOZOAN PARASITE; TRANSFERRIN; ANEMIA; PURIFICATION; ACQUISITION; LACTOFERRIN;

D O I：

10.2217/fmb-2018-0066

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Entamoeba histolytica is a human parasite that causes amoebiasis, a disease that affects the colon and liver and is prevalent worldwide. This protozoan requires a high concentration of iron to survive and reproduce. Iron modulates the expression of parasite virulence factors, including hemoglobinases, hemoglobin-binding proteins and cysteine proteases, as well as proteins related to the amoebic cytoskeleton. This review summarizes the virulence factors that are affected by iron, resulting in upregulation or downregulation of E. histolytica genes. This review also discusses the functionality of iron in the mechanisms of pathogenesis. Graphical abstract [GRAPHICS] .

引用

页码：1329 / 1341

页数：13

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