Lactoferrin-tagged quantum dots-based theranostic nanocapsules for combined COX-2 inhibitor/herbal therapy of breast cancer

被引：65

作者：

AbdElhamid, Ahmed S. ^{[1
,2
]}

Zayed, Dina G. ^{[1
,3
]}

Helmy, Maged W. ^{[1
,4
]}

Ebrahim, Shaker M. ^{[5
]}

Bahey-El-Din, Mohammed ^{[6
]}

Zein-El-Dein, Esmat A. ^{[2
]}

El-Gizawy, Sanaa A. ^{[2
]}

Elzoghby, Ahmed O. ^{[1
,7
,8
]}

机构：

[1] Alexandria Univ, CNRL, Fac Pharm, Alexandria, Egypt

[2] Tanta Univ, Dept Pharmaceut Technol, Fac Pharm, Tanta, Egypt

[3] Alexandria Univ, Dept Ind Pharm, Fac Pharm, Alexandria, Egypt

[4] Damanhour Univ, Dept Pharmacol & Toxicol, Fac Pharm, El Bahira, Egypt

[5] Alexandria Univ, Inst Grad Studies & Res, Dept Mat Sci, Alexandria, Egypt

[6] Alexandria Univ, Fac Pharm, Dept Microbiol & Immunol, Alexandria, Egypt

[7] Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Boston, MA 02115 USA

[8] Harvard MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

NANOMEDICINE | 2018年 / 13卷 / 20期

关键词：

cancer imaging; cancer theranostics; celecoxib; chondroitin sulfate; honokiol; lactoferrin-QDs conjugate; self-targeted nanocapsules; DRUG-DELIVERY; IN-VITRO; PROTAMINE NANOCAPSULES; MOLECULAR-WEIGHT; CO-DELIVERY; NANOPARTICLES; ACID; CDTE; DOXORUBICIN; LIPOSOMES;

D O I：

10.2217/nnm-2018-0196

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Herein, tumor-targeted quantum dots (QDs)-based theranostic nanocapsules (NCs) coloaded with celecoxib and honokiol were developed. Materials & methodology: The anionic CD44-targeting chondroitin sulfate and cationic low density lipoprotein (LDL)-targeting lactoferrin (LF) were sequentially assembled onto the surface of the positively charged oily core. As an imaging probe, highly fluorescent mercaptopropionic acid-capped cadmium telluride QDs were coupled to LF. Results: In vitro, fluorescence of QDs was quenched (OFF state) due to combined electron/energy transfer-mediated processes involving LF. After intracellular uptake of NCs, fluorescence was restored (ON state), thus enabled tracing their internalization. The NCs demonstrated enhanced cytotoxicity against breast cancer cells as well as superior in vivo antitumor efficacy. Conclusion: We propose these multifunctional nanotheranostics for imaging and targeted therapy of breast cancer.

引用

页码：2637 / 2656

页数：20

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