A systematic review of task-based functional neuroimaging studies investigating language, semantic and executive processes in thought disorder

被引:29
作者
Sumner, Philip J. [1 ,2 ,3 ]
Bell, Imogen H. [1 ,2 ,3 ]
Rossell, Susan L. [1 ,2 ,3 ,4 ]
机构
[1] Swinburne Univ Technol, Fac Hlth Arts & Design, Ctr Mental Hlth, Melbourne, Vic, Australia
[2] Monash Univ, Cent Clin Sch, Monash Alfred Psychiat Res Ctr MAPrc, Melbourne, Vic, Australia
[3] Alfred Hosp, Melbourne, Vic, Australia
[4] St Vincents Hosp, Psychiat, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
Thought disorder; Disorganised speech; Schizophrenia; Psychosis; Neuroimaging; Functional magnetic resonance imaging (fMRI); Single photon emission computed tomography (SPECT); Positron emission tomography (PET); NEGATIVE-SYNDROME-SCALE; FORMAL THOUGHT; WORKING-MEMORY; SCHIZOPHRENIC-PATIENTS; COMMUNICATION DISTURBANCES; SELECTIVE ATTENTION; LESION LOCALIZATION; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; BASAL GANGLIA;
D O I
10.1016/j.neubiorev.2018.08.005
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The aim of the current systematic review was to synthesise the research that has investigated thought disorder (TD) using task-based functional neuroimaging techniques to target executive, language, or semantic functions. Thirty-five pertinent studies were identified from January 1990 to August 2016. Functional correlates of TD included the superior and middle temporal, fusiform, and inferior frontal gyri bilaterally, as well as the left and right cingulate cortex, the right caudate nucleus, and the cerebellum. TD-related increases and decreases in activation were both evident in most of these regions. However, the specificity of these correlates from general clinical and cognitive influences is unknown. The cortical regions implicated overlap with those thought to contribute to language and semantic systems. Cortico-striatal circuitry may also play a role in some aspects of TD through aberrant salience representation and inappropriate attentional prioritisation. To advance the field further, greater integration across structural, functional, and behavioural measures is required, in addition to non-unitary considerations of TD.
引用
收藏
页码:59 / 75
页数:17
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