Synthesis, antioxidant and toxicological study of novel pyrimido quinoline derivatives from 4-hydroxy-3-acyl quinolin-2-one

被引：95

作者：

Sankaran, Mathan ^{[1
]}

Kumarasamy, Chandraprakash ^{[1
]}

Chokkalingam, Uvarani ^{[1
]}

Mohan, Palathurai Subramaniam ^{[1
]}

机构：

[1] Bharathiar Univ, Dept Chem, Sch Chem Sci, Coimbatore 641046, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 23期

关键词：

Pyrimido; Triazepine quinolines; Antioxidant activities; Toxicity; BIGINELLI REACTION; CRYPTOSANGUINOLENTINE; MECHANISM; SYSTEMS;

D O I：

10.1016/j.bmcl.2010.09.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel pyrimido and other fused quinoline derivatives like 4-methyl pyrimido [5,4-c]quinoline-2,5(1H,6H)-dione (4a), 4-methyl-2-thioxo-1,2-dihydropyrimido [5,4-c]quinoline-5(6H)-one (4b), 2-amino-4-methyl-1,2-dihydropyrimido [5,4-c]quinolin-5(6H)-one (4c), 3-methylisoxazolo [4,5-c]quinolin-4(5H)-one (4d), 3-methyl-1H-pyrazolo [4,3-c]quinoline-4(5H)-one (5e), 5-methyl-1H-[1,2,4] triazepino [6,5-c]quinoline-2,6(3H,7H)-dione (5f), 5-methyl-2-thioxo-2,3-dihydro-1H-[1,2,4]triazepino [6,5-c]quinolin-6(7H)one (5g) were synthesized regioselectively from 4-hydroxy-3-acyl quinolin-2-one 3. They were screened for their in vitro antioxidant activities against radical scavenging capacity using DPPH, Trolox equivalent antioxidant capacity (TEAC), total antioxidant activity by FRAP, superoxide radical (O-2(degrees-)) scavenging activity, metal chelating activity and nitric oxide scavenging activity. Among the compounds screened, 4c and 5g exhibited significant antioxidant activities. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7147 / 7151

页数：5

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