Ruthenium-Catalyzed C-H Alkynylation of Aromatic Amides with Hypervalent Iodine-Alkyne Reagents

被引：47
作者：
Boobalan, Ramadoss [1 ]
Gandeepan, Parthasarathy [1 ]
Cheng, Chien-Hong [1 ]
机构：
[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 14期
关键词：
BOND ACTIVATION; MILD; FUNCTIONALIZATION; ARENES; ALKENYLATION; HETEROARENES; HYDROCARBONS; BENZAMIDES; RH(III); AZIDES;
D O I：
10.1021/acs.orglett.6b01281
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient C-H activation method for the ortho alkynylation of aromatic N-methoxyamides with hypervalent iodine-alkyne reagent using a ruthenium catalyst is described. The reaction proceeds under mild reaction conditions with broad substrate scope. A possible catalytic cycle involving a ruthenium carboxylate assisted C-H bond cleavage is proposed from the preliminary mechanistic evidence.
引用
收藏
页码：3314 / 3317
页数：4
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