Living unrelated donor kidney transplantation - a fourteen-year experience

被引：2

作者：

Ignjatovic, Ljiljana ^{[1
]}

Jovanovic, Dragan

Kronja, Goran ^{[2
]}

Dujic, Aleksandar ^{[3
]}

Maric, Mihailo

Ignjatovic, Dragan ^{[2
]}

Hrvacevic, Rajko

Kovacevic, Zoran

Petrovic, Milija ^{[2
]}

Elakovic, Dejan ^{[4
]}

Marenovic, Tomislav ^{[5
]}

Lukic, Zoran ^{[5
]}

Trkuljic, Miroljub ^{[7
]}

Stankovic, Bratislav ^{[7
]}

Maksic, Doko

Butorajac, Josip

Colic, Miodrag ^{[3
]}

Draskovic-Pavlovic, Biljana ^{[3
]}

Kapulica-Kuljic, Nada ^{[10
]}

Dragkovic, Nada ^{[10
]}

Misovic, Sidor ^{[2
]}

Stijelja, Borislav ^{[4
]}

Milovic, Novak ^{[4
]}

Tosevski, Perica ^{[4
]}

Filipovic, Nikola ^{[5
]}

Romic, Predrag ^{[5
]}

Jevtic, Miodrag ^{[2
]}

Draskovic, Miroljub ^{[2
]}

Vavic, Neven

Paunic, Zoran

Radojevic, Milorad

Bjelanovic, Zoran ^{[2
]}

Tomic, Aleksandar ^{[2
]}

Aleksic, Predrag ^{[4
]}

Kosevic, Branko ^{[4
]}

Mocovic, Dejan ^{[4
]}

Bancevic, Vladimir ^{[4
]}

Magic, Zvonko ^{[3
]}

Vojvodic, Danilo ^{[3
]}

Balint, Bela ^{[7
]}

Ostojic, Gordana ^{[7
]}

Tukic, Ljiljana ^{[11
]}

Murgic, Jadranka ^{[12
]}

Pervulov, Svetozar ^{[8
]}

Rusovic, Sinisa ^{[8
]}

Sjenicic, Goran ^{[8
]}

Bucan, Vesna ^{[9
]}

Milavic-Vujkovic, Merica ^{[9
]}

Jandric, Dusan ^{[6
]}

Raicevic, Ranko ^{[17
]}

机构：

[1] Mil Med Acad, Dept Nephrol, Clin Nephrol, Belgrade 11090, Serbia

[2] Mil Med Acad, Clin Gen & Vasc Surg, Belgrade 11090, Serbia

[3] Mil Med Acad, Inst Med Res, Belgrade 11090, Serbia

[4] Mil Med Acad, Urol Clin, Belgrade 11090, Serbia

[5] Mil Med Acad, Clin Anesthesiol & Intens Care, Belgrade 11090, Serbia

[6] Mil Med Acad, Ctr Clin Pharmacol, Belgrade 11090, Serbia

[7] Mil Med Acad, Inst Transfusiol, Belgrade 11090, Serbia

[8] Mil Med Acad, Inst Radiol, Belgrade 11090, Serbia

[9] Mil Med Acad, Inst Mental Hlth, Belgrade 11090, Serbia

[10] Mil Med Acad, Inst Microbiol Virol & Parasitol, Belgrade 11090, Serbia

[11] Mil Med Acad, Clin Hematol, Belgrade 11090, Serbia

[12] Mil Med Acad, Inst Med Biochem, Belgrade 11090, Serbia

[13] Mil Med Acad, Ctr Hosp Informat Syst, Belgrade 11090, Serbia

[14] Mil Med Acad, Poison Control Ctr, Belgrade 11090, Serbia

[15] Mil Med Acad, Inst Sci Informat, Belgrade 11090, Serbia

[16] Mil Med Acad, Inst Pharm, Belgrade 11090, Serbia

[17] Mil Med Acad, Neurol Clin, Belgrade 11090, Serbia

[18] Mil Med Acad, Inst Pathol, Belgrade 11090, Serbia

来源：

VOJNOSANITETSKI PREGLED | 2010年 / 67卷 / 12期

关键词：

kidney transplantation; tissue donors; treatment outcome; transplantants; graft survival; graft rejection; risk assessment;

D O I：

10.2298/VSP1012998I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. In countries without a national organization for retrieval and distribution of organs of the deceased donors, problem of organ shortage is still not resolved. In order to increase the number of kidney transplantations we started with the program of living unrelated - spousal donors. The aim of this study was to compare treatment outcome and renal graft function in patients receiving the graft from spousal and those receiving ghe graft from living related donors. Method. We retrospectively identified 14 patients who received renal allograft from spousal donors between 1996 and 2009 (group I). The control group consisted of 14 patients who got graft from related donor retrieved from the database and matched than with respect to sex, age, kidney disease, immunological and viral pretransplant status, the initial method of the end stage renal disease treatment and ABO compatibility. In the follow-up period of 41 +/- 38 months we recorded immunosuppressive therapy, surgical complications, episodes of acute rejection, CMV infection and graft function, assessed by serum creatinine levels at the beginning and in the end of the follow-up period. All patients had pretransplant negative cross-match. In ABO incompatible patients pretransplant isoagglutinine titer was zero. Results. The patients with a spousal donor had worse HLA matching. There were no significant differences between the groups in surgical, infective, immunological complications and graft function. Two patients from the group I returned to hemodialysis after 82 and 22 months due to serious comorbidities. Conclusion. In spite of the worse HLA matching, graft survival and function of renal grafts from spousal donors were as good as those retrieved from related donors.

引用

页码：998 / 1002

页数：5

共 15 条

[1] Living-unrelated donor renal transplantation: an alternative to living-related donor transplantation? [J].

Ahmad, Nadeem ;

Ahmed, Kamran ;

Khan, Mohammad Shamim ;

Calder, Francis ;

Mamode, Nizam ;

Taylor, John ;

Koffman, Geoff .

ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, 2008, 90 (03) :247-250

[2]

[Anonymous], organ procurement & transplantation network: national data

[3] Simple "closed-circuit" group-specific immuno adsorption system for ABO-incompatible kidney transplants [J].

Balint, Bela ;

Pavlovic, Mirjana ;

Jevtlc, Miodrag ;

Hrvacevic, Rajko ;

Ignjatovic, Ljlljana ;

Ostojic, Gordana ;

Mijuskovic, Zoran ;

Blagojevic, Radmila ;

Trkuljic, Miroljub .

TRANSFUSION AND APHERESIS SCIENCE, 2007, 36 (03) :225-233

[4] Trends in unrelated-donor kidney transplantation in the developing world [J].

Barsoum, Rashad S. .

PEDIATRIC NEPHROLOGY, 2008, 23 (11) :1925-1929

[5]

Brecher ME, 2005, TECHNICAL MANUAL, P322

[6]

Eytan M, 2009, CURR OPIN ORGAN TRAN, V14, P113

[7] Iranian model of paid and regulated living-unrelated kidney donation [J].

Ghods, Ahad J. ;

Savaj, Shekoufeh .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 1 (06) :1136-1145

[8] Living unrelated donor kidney transplantation [J].

Gjertson, DW ;

Cecka, JM .

KIDNEY INTERNATIONAL, 2000, 58 (02) :491-499

[9] Our first experiences in applying an original method for removal of ABO-isoagglutinins in ABO-incompatible kidney recipients [J].

Ignjatovic, Ljiljana ;

Kovacevic, Zoran ;

Jovanovic, Dragan ;

Vavic, Neven ;

Paunic, Zoran ;

Radojevic, Milorad ;

Rabrenovic, Violeta ;

Obrencevic, Katarina ;

Mijuskovic, Mirjana ;

Draskovic-Pavlovic, Biljana ;

Ostojic, Gordana ;

Balint, Bela ;

Bokonjic, Dubravko .

VOJNOSANITETSKI PREGLED, 2009, 66 (02) :117-122

[10] Guidelines for conducting a psychiatric evaluation of the unrelated kidney donor [J].

Leo, RJ ;

Smith, BA ;

Mori, DL .

PSYCHOSOMATICS, 2003, 44 (06) :452-460

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