Development of sodium alginate-xanthan gum based nanocomposite scaffolds reinforced with cellulose nanocrystals and halloysite nanotubes

被引:74
作者
Kumar, Anuj [1 ,2 ]
Rao, Kummara Madhusudana [1 ,2 ]
Han, Sung Soo [1 ,2 ]
机构
[1] Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Gyongsan 38541, South Korea
[2] Yeungnam Univ, Dept Nano Med & Polymer Mat, 280 Daehak Ro, Gyongsan 38541, South Korea
关键词
Polysaccharide; Halloysite nanotubes; Cellulose nanocrystals; Nanocomposite scaffolds; MECHANICAL-PROPERTIES; COMPOSITE SCAFFOLDS; CLAY NANOTUBES; CROSS-LINKING; HYDROGELS; FILMS;
D O I
10.1016/j.polymertesting.2017.08.030
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Sodium alginate (Alg) and xanthan gum (XG) based nanocomposite scaffolds reinforced with various amounts of cellulose nanocrystals (CNCs) and/or halloysite nanotubes (HNTs) were prepared by freeze-casting/drying method. In this study, the structure-property-performance relationship was mainly focused and analysed. Morphological analysis showed high porosity and pore-interconnectivity (pore channels) in all obtained scaffolds. Structural analysis demonstrates the good interfacial interactions and uniform dispersion of the CNCs and HNTs, involving partial orientation within the polymeric network. The water uptake capacity (from 14.73.7 +/- 0.46 g/g to 11.34 +/- 0.32 g/g) and porosity (from 91.7 +/- 0.81% to 88.5 +/- 0.64%) were reduced. The compressive strengths (in dry state from 91.1 +/- 1.2 kPa to 114.4 +/- 0.6 kPa and in wet state from 9.0 +/- 0.8 kPa to 10.6 +/- 0.8 kPa), thermal stability, cytocompatibility (MC3T3-E1 osteoblastic cells) of the nanocomposite scaffolds improved as compared to Alg and AlgX scaffolds without CNCs and/or HNTs. The obtained scaffolds may be appropriate as scaffolding material in bone tissue engineering. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:214 / 225
页数:12
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