A Highly Sensitive Cefotaxime Electrochemical Detection Technique Based on Graphene Quantum Dots

Antibacterial drugs are one of the greatest achievements in the field of medicine and play an extremely important role in improving human health. However, the human antimicrobial resistance and the harm of residues in animal food to human body have continued to be concerned. In this work, a cefotaxime electrochemical sensor was constructed based on graphene quantum dots and poly(arginine) (Parg) modified electrode. Scanning electron microscopy and Fourier transform infrared spectroscopy showed that L-arginine was polymerized on the electrode surface. The result of electrochemical impedance and cyclic voltammetry further demonstrate that graphene QDS/Parg films can effectively increase the electron transfer rate on the electrode surface, which indicates that the modified electrode can be applied to the quantitative determination of cefotaxime. In the study, the peak current on the electrode showed a good linear relationship with the concentration of cefotaxime. The linear range was 0.07-450 ??M, and the minimum detection limit was 34 nM.