An efficient and facile synthesis of new tetracyclic fused pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones

被引：4

作者：

Gomaa, Mohsen A. -M. ^{[1
]}

Ali, Huda A. ^{[1
]}

机构：

[1] Menia Univ, Dept Chem, Fac Sci, El Minia 61519, Egypt

来源：

MOLECULAR DIVERSITY | 2018年 / 22卷 / 04期

关键词：

Pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolone; Amidrazone; (1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)propanedinitrile; Dearomatization; NITROGEN SYSTEMS BEARING; POTENTIAL ANTI-HIV; ENANTIOSELECTIVE CONSTRUCTION; 1,3-DIPOLAR CYCLOADDITIONS; 1,2,4-TRIAZINE MOIETY; ANTICANCER DRUGS; AMIDRAZONES; FLUORINE;

D O I：

10.1007/s11030-018-9849-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of amidrazones 1a-1i with (1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)propanedinitrile (2) in ethyl acetate solution in one-step reaction led to the formation of unprecedented pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones 3a-3g along with pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-12b-oles 3h-3m in moderate to excellent yields. These novel heterocycles were formed via a Michael addition reaction followed by intramolecular cyclization via a dearomatization process.

引用

页码：969 / 977

页数：9

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