Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism

被引：124

作者：

Tang, Qi ^{[1
]}

Tan, Peng ^{[1
]}

Ma, Ning ^{[1
]}

Ma, Xi ^{[1
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

来源：

NUTRIENTS | 2021年 / 13卷 / 08期

基金：

中国国家自然科学基金;

关键词：

threonine; metabolism; physiological effects; nutrition; intestinal health; INTESTINAL MUCIN SYNTHESIS; AMINO-ACID-METABOLISM; EMBRYONIC STEM-CELLS; DIETARY THREONINE; GROWTH-PERFORMANCE; PROTEIN-SYNTHESIS; BARRIER FUNCTION; IMMUNE-RESPONSE; MUCOSAL BARRIER; SKELETAL-MUSCLE;

D O I：

10.3390/nu13082592

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Threonine (Thr), an essential amino acid for animals and the limiting amino acid in swine and poultry diets, which plays a vital role in the modulation of nutritional metabolism, macromolecular biosynthesis, and gut homeostasis. Current evidence supports that the supplementation of Thr leads to benefits in terms of energy metabolism. Threonine is not only an important component of gastrointestinal mucin, but also acts as a nutritional modulator that influences the intestinal immune system via complex signaling networks, particularly mitogen-activated protein kinase (MAPK) and the target of the rapamycin (TOR) signal pathway. Threonine is also recognized as an indispensable nutrient for cell growth and proliferation. Hence, optimization of Thr requirement may exert a favorable impact on the factors linked to health and diseases in animals. This review focuses on the latest reports of Thr in metabolic pathways and nutritional regulation, as well as the relationship between Thr and relevant physiological functions.

引用

页数：13

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