MGMT gene promoter methylation in humoral tissue as biomarker for lung cancer diagnosis: An update meta-analysis

被引:6
作者
Chen, Bizheng [1 ]
Ying, Xiaozhen [1 ]
Bao, Liming [1 ]
机构
[1] Lishui Cent Hosp, Dept Radiotherapy, 289 Kuocang Rd, Lishui 323000, Zhejiang, Peoples R China
关键词
biomarker; lung cancer diagnosis; meta-analysis; MGMT gene; promoter methylation; EXPRESSION; HYPERMETHYLATION; SPUTUM;
D O I
10.1111/1759-7714.14186
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective To investigate O-6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation in humoral tissue as biomarker for lung cancer diagnosis by pooling relevant open published data. Methods Clinical studies relevant to MGMT gene promoter methylation and lung cancer were systematic electronic searched in the databases of Medline, EMBASE, Ovid, Web of Science, and CNKI. Data of true positive (tp), false positive (fp), false negative (fn), and true negative (tn) were extracted from the included studies and made combination. The diagnostic sensitivity, specificity, diagnostic odds ratio (DOR) and summary receiver operating characteristic (SROC) of MGMT gene methylation for lung cancer diagnosis were pooled. Results Twelve studies were included in the meta-analysis. The diagnostic sensitivity, specificity, DOR were 0.39 (95% CI = 0.31-0.49) 0.92 (95% CI = 0.77-0.97), and 4.20 (95% CI = 2.09-8.44), respectively under random effect model. The SROC of MGMT gene methylation for lung cancer diagnosis was 0.58 (95% CI = 0.53-0.62). Conclusion MGMT methylation rate was higher in plasma and bronchoalveolar lavage fluid (BLAF) of lung cancer cases compared to controls. High diagnostic specificity indicated that MGMT methylation in plasma and BLAF can be applied as lung cancer confirmation test.
引用
收藏
页码:3194 / 3200
页数:7
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