Guanidine based copper(II) complexes: synthesis, structural elucidation, and biological evaluation

被引：0

作者：

Said, Muhammad ^{[1
]}

Khan, Hizbullah ^{[2
]}

Murtaza, Ghulam ^{[3
]}

Sirajuddin, Muhammad ^{[2
]}

Badshah, Amin ^{[3
]}

Salman, Syed Muhammad ^{[4
]}

Gul, Rukhsana ^{[5
]}

Najeebullah ^{[6
]}

机构：

[1] Univ Malakand, Dept Chem, Chakdara, Pakistan

[2] Univ Sci & Technol Bannu, Dept Chem, Bannu, Pakistan

[3] Quaid I Azam Univ Islamabad, Dept Chem, Islamabad, Pakistan

[4] Islamia Coll Peshawar, Dept Chem, Peshawar, Pakistan

[5] Kohat Univ Sci & Technol, Dept Chem, Kohat, Pakistan

[6] Univ Engn & Technol Peshawar, US Pak Ctr Adv Studies Energy, Peshawar, Pakistan

来源：

INORGANIC AND NANO-METAL CHEMISTRY | 2022年 / 53卷 / 05期

关键词：

Guanidine ligand; Copper(II) complex; single crystal X-ray diffraction; antitumor assay; urease inhibition; N-BENZOYLGUANIDINES; UREASE; ANTIBACTERIAL; GUANYLATION; DERIVATIVES; INHIBITORS; DISCOVERY; BINDING;

D O I：

10.1080/24701556.2022.2081185

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cu(II) complexes of substituted Guanidines having common formula [kappa(2)(O, N)-C6H5CONHC(NHR1)NR2](2)Cu(II), in which R-1 = C6H5- and R-2 = C(CH3)(3) (1), CH2CH2CH3 (2), CH(CH3)(2) (3), 2, 6-Cl2C6H3 (4) and 4-CH3C6H4 (5) were synthesized and their structural and chemical characteristics were examined by CHN analyzer, FTIR, NMR Spectrometer (including H-1 and C-13) and magnetic susceptibility balance. Two of the guanidine ligands and their Cu(II) complexes were also analyzed by single crystal X-ray diffraction. The X-ray diffraction analysis revealed that majority of the studied guanidine ligands were stable due to intermolecular and intra-molecular hydrogen bonding. The synthesized compounds are mononuclear having pseudo square planar geometry, whereas guanidine ligands attached to the metal center via oxygen and nitrogen atoms. The metallodrugs demonstrated better urease inhibition action than their parent guanidine ligands and also have shown fairly good score regarding the potato disk bioassay in comparison with the vincristine, employed as a standard drug.

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页码：513 / 522

页数：10

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