Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance

被引:462
作者
Polonsky, KS
Sturis, J
Bell, GI
机构
[1] UNIV CHICAGO,DEPT BIOCHEM,CHICAGO,IL 60637
[2] UNIV CHICAGO,DEPT MOLEC BIOL,CHICAGO,IL 60637
[3] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637
关键词
D O I
10.1056/NEJM199603213341207
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:777 / 783
页数:7
相关论文
共 71 条
[1]   PATHOGENIC ROLE OF AN INSULIN-RECEPTOR DEFECT IN DIABETES-MELLITUS OF OBESE [J].
BECKNIELSEN, H .
DIABETES, 1978, 27 (12) :1175-1181
[2]   GENE FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS (MATURITY-ONSET DIABETES OF THE YOUNG SUBTYPE) IS LINKED TO DNA POLYMORPHISM ON HUMAN CHROMOSOME-20Q [J].
BELL, GI ;
XIANG, KS ;
NEWMAN, MV ;
WU, SH ;
WRIGHT, LG ;
FAJANS, SS ;
SPIELMAN, RS ;
COX, NJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1484-1488
[3]   PHYSIOLOGIC EVALUATION OF FACTORS CONTROLLING GLUCOSE-TOLERANCE IN MAN - MEASUREMENT OF INSULIN SENSITIVITY AND BETA-CELL GLUCOSE SENSITIVITY FROM THE RESPONSE TO INTRAVENOUS GLUCOSE [J].
BERGMAN, RN ;
PHILLIPS, LS ;
COBELLI, C .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (06) :1456-1467
[4]  
BYRNE M, 1995, DIABETES, V44, pA195
[5]   ALTERED INSULIN SECRETORY RESPONSES TO GLUCOSE IN SUBJECTS WITH A MUTATION IN THE MODY1 GENE ON CHROMOSOME-20 [J].
BYRNE, MM ;
STURIS, J ;
FAJANS, SS ;
ORTIZ, FJ ;
STOLTZ, A ;
STOFFEL, M ;
SMITH, MJ ;
BELL, GI ;
HALTER, JB ;
POLONSKY, KS .
DIABETES, 1995, 44 (06) :699-704
[6]   INSULIN SECRETORY ABNORMALITIES IN SUBJECTS WITH HYPERGLYCEMIA DUE TO GLUCOKINASE MUTATIONS [J].
BYRNE, MM ;
STURIS, J ;
CLEMENT, K ;
VIONNET, N ;
PUEYO, ME ;
STOFFEL, L ;
TAKEDA, J ;
PASSA, P ;
COHEN, D ;
BELL, GI ;
VELHO, G ;
FROGUEL, P ;
POLONSKY, KS .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1120-1130
[7]   INSULIN-RECEPTOR KINASE IN HUMAN SKELETAL-MUSCLE FROM OBESE SUBJECTS WITH AND WITHOUT NONINSULIN DEPENDENT DIABETES [J].
CARO, JF ;
SINHA, MK ;
RAJU, SM ;
ITTOOP, O ;
PORIES, WJ ;
FLICKINGER, EG ;
MEELHEIM, D ;
DOHM, GL .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (05) :1330-1337
[8]   ROLE OF GLUCOSE-TRANSPORT IN THE POSTRECEPTOR DEFECT OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
CIARALDI, TP ;
KOLTERMAN, OG ;
SCARLETT, JA ;
KAO, M ;
OLEFSKY, JM .
DIABETES, 1982, 31 (11) :1016-1022
[9]   OBESE AND DIABETES - 2 MUTANT-GENES CAUSING DIABETES-OBESITY SYNDROMES IN MICE [J].
COLEMAN, DL .
DIABETOLOGIA, 1978, 14 (03) :141-148
[10]   INSULIN SENSITIVITY AND INSULIN BINDING TO MONOCYTES IN MATURITY-ONSET DIABETES [J].
DEFRONZO, R ;
DEIBERT, D ;
HENDLER, R ;
FELIG, P ;
SOMAN, V .
JOURNAL OF CLINICAL INVESTIGATION, 1979, 63 (05) :939-946