Stability and flow behaviour of barium sulphate suspension and the preparation of stable barium sulphate suspension for medical use

Stability and flow behaviour of concentrated barium sulphate suspension (BSS) was studied in the presence of sodium carboxy methyl cellulose (NaCMC), bentonite and poly vinyl pyrrolidone (PVP). NaCMC (0.2%) showed maximum viscosity (50%), maximum sedimentation volume of BSS and maximum (0.4%) adsorption of NaCMC by BSS. Bentonite and PVP had no significant effect on sedimentation volume of BSS but increased the viscosity. The radiological studies on the X-ray picture of rabbit using BSS (50%) and NaCMC (0.2%) exhibited poor contrast of the stomach region. To increase the stability, suspension was mixed with tri sodium citrate (4%). The X-ray picture of rabbit showed good contrast of the stomach as well as the small intestine region.