α-Zearalanol, a phytoestrogen for cardiovascular therapy

被引:15
作者
Dai, SL [1 ]
Duan, JH
Lu, Y
Cheng, JX
Ren, J
Deng, WH
Wu, YY
机构
[1] Peking Union Med Coll, Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China
[2] Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA
[3] Beijing Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100730, Peoples R China
关键词
phytoestrogen; estrogen; cardiovascular; atherosclerosis; uterine growth;
D O I
10.1385/ENDO:25:2:117
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Estrogen replacement therapy (ERT) is one of the most challenging issues women and their physicians have to face. Clinical and epidemiological studies have provided conflicting data regarding the cardiovascular benefit versus risk in women using ERT. Although ERT may improve several risk factors of coronary heart disease such as favorable changes in lipid profile, an associated increased incidence of uterine and breast tumors has jeopardized the clinical use of ERT. We reported here that the phytoestrogen alpha-zearalanol is effective against atherosclerotic development without overt growth-promoting effects in the uterus compared to estrogen. These results suggest clinical potential of this phytoestrogen as a "safe estrogen" with less risk of tumorogenesis.
引用
收藏
页码:117 / 119
页数:3
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