Diagnostic value of GLUT-1 in distinguishing malignant mesothelioma from reactive mesothelial cells: a meta-analysis

被引:5
|
作者
Zhong, Shan-Chuan [1 ]
Ao, Xu-Jun [2 ]
Yu, Shang-Hai [1 ]
机构
[1] Peoples Liberat Army, Dept Pathol & Clin Lab, Army Hosp 96601, Huangshan 245041, Anhui, Peoples R China
[2] Peoples Liberat Army, Dept Med Oncol, Army Hosp 96601, Huangshan, Peoples R China
关键词
Glucose transporter 1; malignant mesothelioma; reactive mesothelial cells; diagnostic value; meta-analysis; IMMUNOHISTOCHEMICAL DETECTION; DIFFERENTIAL-DIAGNOSIS; PATHOLOGICAL DIAGNOSIS; DISTINGUISHING BENIGN; GLUCOSE TRANSPORTERS; CONSENSUS STATEMENT; P16; FISH; EXPRESSION; GLUCOSE-TRANSPORTER-1; HYPERPLASIA;
D O I
10.1080/1354750X.2020.1714735
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: Previous studies have demonstrated the diagnostic value of glucose transporter 1 (GLUT-1) to distinguish malignant mesothelioma (MM) from reactive mesothelial cells (RMC), but the results are inconsistent. The purpose of this meta-analysis is to investigate the diagnostic accuracy of GLUT-1 in distinguishing MM from RMC. Methods: A systematical search was conducted until May 2019 in PubMed, Medline, Embase and the Cochrane Library. The revised tool for the quality assessment of diagnostic accuracy studies (QUADAS-2) was used to assess the quality of the eligible studies. The Stata15 and Review Manager5.3 software programmes were used to perform the meta-analysis. Results: A total of 24 studies, including 969 MM patients and 1080 RMC individuals were explored in the meta-analysis. The summary assessments revealed that the pooled sensitivity was 0.73 (95% CI, 0.62-0.81) and the pooled specificity was 0.95 (95% CI, 0.91-0.98). The area under the summary ROC curve (AUC) was 0.93 (95% CI: 0.91-0.95). Conclusions: GLUT-1 is highly accurate to distinguish MM from RMC.
引用
收藏
页码:157 / 163
页数:7
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