Soluble intercellular adhesion molecule-1 is associated with hepatocellular carcinoma risk: multiplex analysis of serum markers

被引:13
作者
Chen, Vincent L. [1 ,2 ]
Le, An K. [3 ]
Podlaha, Ondrej [4 ]
Estevez, Jacqueline [3 ,5 ]
Li, Biao [4 ]
Vutien, Philip [6 ]
Chang, Ellen T. [7 ]
Rosenberg-Hasson, Yael [8 ]
Pflanz, Stefan [4 ]
Jiang, Zhaoshi [4 ]
Ge, Dongliang [4 ]
Gaggar, Anuj [4 ]
Nguyen, Mindie H. [3 ]
机构
[1] Stanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
[2] Univ Michigan Hlth Syst, Div Gastroenterol, Ann Arbor, MI USA
[3] Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
[4] Gilead Sci, Foster City, CA USA
[5] Boston Univ, Sch Med, Boston, MA 02118 USA
[6] Rush Univ, Med Ctr, Dept Med, Chicago, IL 60612 USA
[7] Stanford Univ, Sch Med, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA
[8] Stanford Univ, Sch Med, Inst Immun Transplantat & Infect Operat, Stanford, CA 94305 USA
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词
CHRONIC HEPATITIS-C; LIVER-CANCER; INTERLEUKIN-6; HEPATOCARCINOGENESIS; EXPRESSION; PROGNOSIS; ICAM-1; VIRUS; CORRELATE; LEVEL;
D O I
10.1038/s41598-017-10498-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Individualized assessment of hepatocellular carcinoma (HCC) risk in chronic liver disease remains challenging. Serum biomarkers including cytokines may offer helpful adjuncts to standard parameters for risk prediction. Our aim was to identify markers associated with increased HCC incidence. This was a prospective cohort study of 282 patients with both viral or non-viral chronic liver disease. Baseline serum cytokines and other markers were measured in multiplex with a commercially-available Luminex-based system. Patients were followed until death or HCC diagnosis. We performed Lasso-based survival analysis to determine parameters associated with HCC development. Cytokine mean florescence intensity (MFI) was the primary predictor and HCC development the primary outcome. 25 patients developed HCC with total follow-up of 1,363 person-years. Parameters associated with increased HCC incidence were cirrhosis, hepatic decompensation, and soluble serum intercellular adhesion molecule 1 (sICAM-1) MFI. No other molecules increased predictive power for HCC incidence. On univariate analysis, the parameters associated with HCC incidence in patients with cirrhosis were age, antiviral treatment, and high sICAM-1 MFI; on multivariate analysis, sICAM-1 remained associated with HCC development (adjusted HR = 2.75). On unbiased screening of serum cytokines and other markers in a diverse cohort, baseline sICAM-1 MFI is associated with HCC incidence.
引用
收藏
页数:9
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