Safety Assessment of PEGylated Oils as Used in Cosmetics

被引：12

作者：

Burnett, Christina L. ^{[1
]}

Heldreth, Bart ^{[2
]}

Bergfeld, Wilma F. ^{[3
]}

Belsito, Donald V. ^{[3
]}

Hill, Ronald A. ^{[3
]}

Klaassen, Curtis D. ^{[3
]}

Liebler, Daniel C. ^{[3
]}

Marks, James G., Jr. ^{[3
]}

Shank, Ronald C. ^{[3
]}

Slaga, Thomas J. ^{[3
]}

Snyder, Paul W. ^{[3
]}

Andersen, F. Alan ^{[4
]}

机构：

[1] Cosmet Ingredient Review Sci Analyst Writer, Washington, DC USA

[2] Cosmet Ingredient Review Chem, Washington, DC USA

[3] Cosmet Ingredient Review Expert Panel Member, Washington, DC USA

[4] Cosmet Ingredient Rev, Washington, DC USA

来源：

INTERNATIONAL JOURNAL OF TOXICOLOGY | 2014年 / 33卷

关键词：

PEGylated oils; cosmetics; safety; FORMULATION; MICROEMULSION; CYCLOSPORINE; PERMEATION; CREMOPHOR; DELIVERY; SOLVENT;

D O I：

10.1177/1091581814546337

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

PEGylated oil is a terminology used to describe cosmetic ingredients that are the etherification and esterification products of glycerides and fatty acids with ethylene oxide. The Cosmetic Ingredient Review Expert Panel (Panel) considered the safety of PEGylated oils, which function primarily as surfactants in cosmetic products. The Panel reviewed relevant animal and human data provided in this safety assessment and concluded that the 130 chemically related PEGylated oils were safe as cosmetic ingredients in the present practices of use and concentration when formulated to be nonirritating.

引用

页码：13S / 39S

页数：27

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