Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes?

被引：30

作者：

Yu, Cai-Guo ^{[1
,2
]}

Zhang, Ning ^{[1
,2
]}

Yuan, Sha-Sha ^{[1
,2
]}

Ma, Yan ^{[1
,2
]}

Yang, Long-Yan ^{[1
,2
]}

Feng, Ying-Mei ^{[1
,2
]}

Zhao, Dong ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Key Lab Diabet Prevent & Res, Luhe Hosp, Beijing 101149, Peoples R China

[2] Capital Med Univ, Luhe Hosp, Dept Endocrinol, Beijing 101149, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2016年 / 2016卷

关键词：

NITRIC-OXIDE SYNTHASE; HEMATOPOIETIC STEM-CELLS; GROWTH-FACTOR; HIGH GLUCOSE; BONE-MARROW; METABOLIC MEMORY; GLYCEMIC CONTROL; GENE-EXPRESSION; FOLLOW-UP; RETINOPATHY;

D O I：

10.1155/2016/1803989

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Despite being featured as metabolic disorder, diabetic patients are largely affected by hyperglycemia-induced vascular abnormality. Accumulated evidence has confirmed the beneficial effect of endothelial progenitor cells (EPCs) in coronary heart disease. However, antivascular endothelial growth factor (anti-VEGF) treatment is the main therapy for diabetic retinopathy and nephropathy, indicating the uncertain role of EPCs in the pathogenesis of diabetic microvascular disease. In this review, we first illustrate how hyperglycemia induces metabolic and epigenetic changes in EPCs, which exerts deleterious impact on their number and function. We then discuss how abnormal angiogenesis develops in eyes and kidneys under diabetes condition, focusing on "VEGF uncoupling with nitric oxide" and "competitive angiopoietin 1/angiopoietin 2" mechanisms that are shared in both organs. Next, we dissect the nature of EPCs in diabetic microvascular complications. After we overview the current EPCs-related strategies, we point out new EPCs-associated options for future exploration. Ultimately, we hope that this review would uncover the mysterious nature of EPCs in diabetic microvascular disease for therapeutics.

引用

页数：10

共 92 条

[1] Role of NADPH oxidase in retinal vascular inflammation [J].

Al-Shabrawey, Mohamed ;

Rojas, Modesto ;

Sanders, Tammy ;

Behzadian, Ali ;

El-Remessy, Azza ;

Bartoli, Manuela ;

Parpia, Abdul Kader ;

Liou, Gregory ;

Caldwell, Ruth B. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2008, 49 (07) :3239-3244

[2] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[3] Endothelial Dysfunction in Diabetes The role of reparatory mechanisms [J].

Avogaro, Angelo ;

Albiero, Mattia ;

Menegazzo, Lisa ;

de Kreutzenberg, Saula ;

Fadini, Gian Paolo .

DIABETES CARE, 2011, 34 :S285-S290

[4] Association of blood glucose control and pancreatic reserve with diabetic retinopathy in the Veterans Affairs Diabetes Trial (VADT) [J].

Azad, Nasrin ;

Agrawal, Lily ;

Emanuele, Nicholas V. ;

Klein, Ronald ;

Bahn, Gideon D. ;

Reaven, Peter .

DIABETOLOGIA, 2014, 57 (06) :1124-1131

[5] Erythropoietin regulates endothelial progenitor cells [J].

Bahlmann, FH ;

de Groot, K ;

Spandau, JM ;

Landry, AL ;

Hertel, B ;

Duckett, T ;

Boehm, SM ;

Menne, J ;

Haller, H ;

Fliser, D .

BLOOD, 2004, 103 (03) :921-926

[6] The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis [J].

Bentley, Katie ;

Franco, Claudio Areias ;

Philippides, Andrew ;

Blanco, Raquel ;

Dierkes, Martina ;

Gebala, Veronique ;

Stanchi, Fabio ;

Jones, Martin ;

Aspalter, Irene M. ;

Cagna, Guiseppe ;

Westrom, Simone ;

Claesson-Welsh, Lena ;

Vestweber, Dietmar ;

Gerhardt, Holger .

NATURE CELL BIOLOGY, 2014, 16 (04) :309-+

[7] Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes [J].

Bhatta, Maulasri ;

Ma, Jacey Hongjie ;

Wang, Joshua J. ;

Sakowski, Jonna ;

Zhang, Sarah X. .

DIABETOLOGIA, 2015, 58 (09) :2181-2190

[8] Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock [J].

Busik, Julia V. ;

Tikhonenko, Maria ;

Bhatwadekar, Ashay ;

Opreanu, Madalina ;

Yakubova, Nafissa ;

Caballero, Sergio ;

Player, Danny ;

Nakagawa, Takahiko ;

Afzal, Aqeela ;

Kielczewski, Jennifer ;

Sochacki, Andrew ;

Hasty, Stephanie ;

Calzi, Sergio Li ;

Kim, Sungjin ;

Duclas, Shane K. ;

Segal, Mark S. ;

Guberski, Dennis L. ;

Esselman, Walter J. ;

Boulton, Michael E. ;

Grant, Maria B. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (13) :2897-2906

[9] Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy [J].

Cahoon, Judd M. ;

Rai, Ruju R. ;

Carroll, Lara S. ;

Uehara, Hironori ;

Zhang, Xiaohui ;

O'Neil, Christina L. ;

Medina, Reinhold J. ;

Das, Subtrata K. ;

Muddana, Santosh K. ;

Olson, Paul R. ;

Nielson, Spencer ;

Walker, Kortnie ;

Flood, Maggie M. ;

Messenger, Wyatt B. ;

Archer, Bonnie J. ;

Barabas, Peter ;

Krizaj, David ;

Gibson, Christopher C. ;

Li, Dean Y. ;

Koh, Gou Y. ;

Gao, Guangping ;

Stitt, Alan W. ;

Ambati, Balamurali K. .

DIABETES, 2015, 64 (12) :4247-4259

[10] c-Kit plus progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway [J].

Campagnolo, Paola ;

Tsai, Tsung-Neng ;

Hong, Xuechong ;

Kirton, John Paul ;

So, Po-Wah ;

Margariti, Andriana ;

Di Bernardini, Elisabetta ;

Wong, Mei Mei ;

Hu, Yanhua ;

Stevens, Molly M. ;

Xu, Qingbo .

BIOMATERIALS, 2015, 60 :53-61

← 1 2 3 4 5 6 7 8 9 10 →