Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's "magic (nano)bullet" for cancer theranostics?

被引:68
作者
Datta, N. R. [1 ]
Krishnan, S. [2 ]
Speiser, D. E. [3 ]
Neufeld, E. [4 ]
Kuster, N. [4 ,5 ]
Bodis, S. [1 ,6 ]
Hofmann, H. [7 ]
机构
[1] Kantonsspital Aarau, KSA KSB, Ctr Radiat Oncol, Tellstr, CH-5001 Aarau, Switzerland
[2] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
[3] Univ Lausanne, Fac Biol & Med, Ludwig Canc Res, Dept Oncol, Lausanne, Switzerland
[4] ITIS Fdn Res Informat Technol Soc, Zurich, Switzerland
[5] Swiss Fed Inst Technol, Zurich, Switzerland
[6] Univ Zurich Hosp, Dept Radiat Oncol, Zurich, Switzerland
[7] Ecole Polytech Fed Lausanne, Inst Mat, Lab Powder Technol, Lausanne, Switzerland
关键词
Magnetic nanoparticle; Hyperthermia; Cancer theranostics; Treatment planning; Targeted drug delivery; Gene silencing; IRON-OXIDE NANOPARTICLES; CD8; T-CELLS; ENHANCED PERMEABILITY; LOCAL HYPERTHERMIA; TARGETED THERAPY; DELIVERY-SYSTEMS; PROSTATE-CANCER; DRUG-DELIVERY; STEM-CELLS; IN-VITRO;
D O I
10.1016/j.ctrv.2016.09.016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthermia at 39-45 degrees C is a potent radiosensitiser and has been shown to improve therapeutic outcomes in various tumours through its synergy with chemotherapy. Gene silencing approaches, using small interfering RNAs and microRNAs, are also being explored in clinical trials in oncology. The rapid developments in multifunctional nanoparticles provide ample opportunities to integrate both diagnostic and therapeutic modalities into a single effective cancer "theranostic" vector. Nanoparticles could extravasate passively into the tumour tissues in preference to the adjacent normal tissues by capitalizing on the enhanced permeability and retention effect. Tumour targeting might be further augmented by conjugating tumour-specific peptides and antibodies onto the surface of these nanoparticles or by activation through electromagnetic radiations, laser or ultrasound. Magnetic nanoparticles can induce hyperthermia in the presence of an alternating magnetic field, thereby multifunctionally with tumour-specific payloads empowering tumour specific radiotheranostics (for both imaging and radiotherapy), chemotherapy drug delivery, immunotherapy and gene silencing therapy. Such a (nano)bullet could realise the "magic bullet" conceived by Paul Ehrlich more than a century ago. This article discusses the various aspects of this "magic (nano)bullet" and the challenges that need to be addressed to usher in this new paradigm in modern cancer diagnostics and therapeutics. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:217 / 227
页数:11
相关论文
共 110 条
[1]   Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired [J].
Ahmadzadeh, Mojgan ;
Johnson, Laura A. ;
Heemskerk, Bianca ;
Wunderlich, John R. ;
Dudley, Mark E. ;
White, Donald E. ;
Rosenberg, Steven A. .
BLOOD, 2009, 114 (08) :1537-1544
[2]   Unique roles of nanotechnology in medicine and cancer-II [J].
Alam, F. ;
Naim, M. ;
Aziz, M. ;
Yadav, N. .
INDIAN JOURNAL OF CANCER, 2015, 52 (01) :1-+
[3]   Cell-mediated delivery of nanoparticles: Taking advantage of circulatory cells to target nanoparticles [J].
Anselmo, Aaron C. ;
Mitragotri, Samir .
JOURNAL OF CONTROLLED RELEASE, 2014, 190 :531-541
[4]   A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages [J].
Araki, N ;
Johnson, MT ;
Swanson, JA .
JOURNAL OF CELL BIOLOGY, 1996, 135 (05) :1249-1260
[5]   Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns [J].
Bachmann, Martin F. ;
Jennings, Gary T. .
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (11) :787-796
[6]   The Promise of MicroRNA Replacement Therapy [J].
Bader, Andreas G. ;
Brown, David ;
Winkler, Matthew .
CANCER RESEARCH, 2010, 70 (18) :7027-7030
[7]   Applications of nanoparticles for diagnosis and therapy of cancer [J].
Baetke, S. C. ;
Lammers, T. ;
Kiessling, F. .
BRITISH JOURNAL OF RADIOLOGY, 2015, 88 (1054)
[8]   The three main stumbling blocks for anticancer T cells [J].
Baitsch, Lukas ;
Fuertes-Marraco, Silvia A. ;
Legat, Amandine ;
Meyer, Christiane ;
Speiser, Daniel E. .
TRENDS IN IMMUNOLOGY, 2012, 33 (07) :364-372
[9]   Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients [J].
Baitsch, Lukas ;
Baumgaertner, Petra ;
Devevre, Estelle ;
Raghav, Sunil K. ;
Legat, Amandine ;
Barba, Leticia ;
Wieckowski, Sebastien ;
Bouzourene, Hanifa ;
Deplancke, Bart ;
Romero, Pedro ;
Rufer, Nathalie ;
Speiser, Daniel E. .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) :2350-2360
[10]   The role of recent nanotechnology in enhancing the efficacy of radiation therapy [J].
Bergs, Judith W. J. ;
Wacker, Matthias G. ;
Hehlgans, Stephanie ;
Piiper, Albrecht ;
Multhoff, Gabriele ;
Roedel, Claus ;
Roedel, Franz .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2015, 1856 (01) :130-143