Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response

被引:29
作者
Brackman, Deanna J. [1 ]
Giacomini, Kathleen M. [1 ,2 ]
机构
[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA
关键词
CANCER RESISTANCE PROTEIN; CELL LUNG-CANCER; BREAST-CANCER; MULTIDRUG-RESISTANCE; ROSUVASTATIN PHARMACOKINETICS; GENETIC POLYMORPHISMS; ALZHEIMERS-DISEASE; TRANSPORTER ABCG2; RISK-FACTORS; PHASE-II;
D O I
10.1002/cpt.903
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Reverse translational research takes a bedside-to-bench approach, using sophisticated basic research to explain the biological mechanisms behind observed clinical data. For transporters, which play a role in human disease and drug response, this approach offers a distinct advantage over the typical translational research, which often falters due to inadequate in vitro and preclinical animal models. Research on ABCG2, which encodes the Breast Cancer Resistance Protein, has benefited immensely from a reverse translational approach due to its broad implications for disease susceptibility and both therapeutic and adverse drug response. In this review, we describe the success of reverse translational research for ABCG2 and opportunities for further studies.
引用
收藏
页码:233 / 242
页数:10
相关论文
共 75 条
[71]  
Yamamoto Akira, 2002, J Atheroscler Thromb, V9, P48
[72]   Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors [J].
Yang, Qiong ;
Koettgen, Anna ;
Dehghan, Abbas ;
Smith, Albert V. ;
Glazer, Nicole L. ;
Chen, Ming-Huei ;
Chasman, Daniel I. ;
Aspelund, Thor ;
Eiriksdottir, Gudny ;
Harris, Tamara B. ;
Launer, Lenore ;
Nalls, Michael ;
Hernandez, Dena ;
Arking, Dan E. ;
Boerwinkle, Eric ;
Grove, Megan L. ;
Li, Man ;
Kao, W. H. Linda ;
Chonchol, Michel ;
Haritunians, Talin ;
Li, Guo ;
Lumley, Thomas ;
Psaty, Bruce M. ;
Shlipak, Michael ;
Hwang, Shih-Jen ;
Larson, Martin G. ;
O'Donnell, Christopher J. ;
Upadhyay, Ashish ;
van Duijn, Cornelia M. ;
Hofman, Albert ;
Rivadeneira, Fernando ;
Stricker, Bruno ;
Uitterlinden, Andre G. ;
Pare, Guillaume ;
Parker, Alex N. ;
Ridker, Paul M. ;
Siscovick, David S. ;
Gudnason, Vilmundur ;
Witteman, Jacqueline C. ;
Fox, Caroline S. ;
Coresh, Josef .
CIRCULATION-CARDIOVASCULAR GENETICS, 2010, 3 (06) :523-530
[73]   Ensembl 2016 [J].
Yates, Andrew ;
Akanni, Wasiu ;
Amode, M. Ridwan ;
Barrell, Daniel ;
Billis, Konstantinos ;
Carvalho-Silva, Denise ;
Cummins, Carla ;
Clapham, Peter ;
Fitzgerald, Stephen ;
Gil, Laurent ;
Giron, Carlos Garcia ;
Gordon, Leo ;
Hourlier, Thibaut ;
Hunt, Sarah E. ;
Janacek, Sophie H. ;
Johnson, Nathan ;
Juettemann, Thomas ;
Keenan, Stephen ;
Lavidas, Ilias ;
Martin, Fergal J. ;
Maurel, Thomas ;
McLaren, William ;
Murphy, Daniel N. ;
Nag, Rishi ;
Nuhn, Michael ;
Parker, Anne ;
Patricio, Mateus ;
Pignatelli, Miguel ;
Rahtz, Matthew ;
Riat, Harpreet Singh ;
Sheppard, Daniel ;
Taylor, Kieron ;
Thormann, Anja ;
Vullo, Alessandro ;
Wilder, Steven P. ;
Zadissa, Amonida ;
Birney, Ewan ;
Harrow, Jennifer ;
Muffato, Matthieu ;
Perry, Emily ;
Ruffier, Magali ;
Spudich, Giulietta ;
Trevanion, Stephen J. ;
Cunningham, Fiona ;
Aken, Bronwen L. ;
Zerbino, Daniel R. ;
Flicek, Paul .
NUCLEIC ACIDS RESEARCH, 2016, 44 (D1) :D710-D716
[74]   Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer [J].
Yoh, K ;
Ishii, G ;
Yokose, T ;
Minegishi, Y ;
Tsuta, K ;
Goto, K ;
Nishiwaki, Y ;
Kodama, T ;
Suga, M ;
Ochiai, A .
CLINICAL CANCER RESEARCH, 2004, 10 (05) :1691-1697
[75]   Role of BCRP 421C>A polymorphism on rosuvastatin pharynacokinetics in healthy Chinese males [J].
Zhang, Wei ;
Yu, Bang-Ning ;
He, Yi-Jing ;
Fan, Lan ;
Li, Qing ;
Liu, Zhao-Qian ;
Wang, An ;
Liu, Ya-Li ;
Tan, Zhi-Rong ;
Fen-Jiang ;
Huang, Yuan-Fei ;
Zhou, Hong-Hao .
CLINICA CHIMICA ACTA, 2006, 373 (1-2) :99-103