New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells

被引：34
作者：
Li, Wei
Huang, Xin
Yang, Xiu-Wei
机构：
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100871, Peoples R China
来源：
FITOTERAPIA | 2012年 / 83卷 / 02期
关键词：
Tussilago farfara L; Compositae; Sesquiterpenoids; Nitric oxide; OCCURRING TERPENE DERIVATIVES; NITRIC-OXIDE; CONSTITUENTS; FLOS;
D O I：
10.1016/j.fitote.2011.11.011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new sesquiterpenoids, 1 alpha-(3 ''-ethyl-cis-crotonoyloxy)-8-angeloyloxy-3 beta,4 beta-epoxybisabola-7(14),10-diene (1), 7 beta-angeloyloxy-14-hydroxy-notonipetranone (2) and 1 alpha-hydroxy-7 beta-(4-methylsenecioyloxy)-oplopa-3(14)Z,8(10)-dien-2-one (3) were isolated from ethanolic extract of the dried flower buds of Tussilago farfara L, along with nine known sesquiterpenoids (4-12). All of these compounds were evaluated for their effect on the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited inhibitory activity on NO production in a dose-dependent manner. 7 beta-(4-Methylsenecioyloxy)-oplopa-3(14)E,8(10)-dien-2-one (8) was proved to be the best among these tested sesquiterpenoids with an IC50 value of 10.80 mu M. (C) 2011 Elsevier B.V. All rights reserved.
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页码：318 / 322
页数：5
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