Palladium-catalyzed intermolecular cyclocarbonylation of 2-iodoanilines with N-toluenesulfonyl aldimines

被引：6
作者：
Okuro, Kazumi [1 ]
Alper, Howard [1 ]
机构：
[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 20期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Cyclocarbonylation; Quinazolinone; Palladium; N-Toluenesulfonyl aldimines; EFFICIENT SYNTHESIS; DERIVATIVES; FACILE;
D O I：
10.1016/j.tetlet.2012.03.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A single step synthesis of 2,3-dihydro-4(1H)-quinazolinones is described using palladium-catalyzed cyclocarbonylation of 2-iodoanilines with N-toluenesulfonyl aldimines. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2540 / 2542
页数：3
相关论文
共 30 条
  • [1] Brown M. L., 2007, U.S. Patent Application, Patent No. [2007/0134161, 20070134161]
  • [2] Chemla F., 2000, SYNTHESIS-STUTTGART, V16, P75
  • [3] Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes
    Cheng, Xu
    Vellalath, Sreekumar
    Goddard, Richard
    List, Benjamin
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (47) : 15786 - +
  • [4] Palladium-Catalyzed Carboxamidation Reaction and Aldol Condensation Reaction Cascade: A Facile Approach to Ring-Fused Isoquinolinones
    Chouhan, Gagan
    Alper, Howard
    [J]. ORGANIC LETTERS, 2008, 10 (21) : 4987 - 4990
  • [5] Domino Ring-Opening/Carboxamidation Reactions of N-Tosyl Aziridines and 2-Halophenols/Pyridinol: Efficient Synthesis of 1,4-Benzo- and Pyrido-oxazepinones
    Chouhan, Gagan
    Alper, Howard
    [J]. ORGANIC LETTERS, 2010, 12 (01) : 192 - 195
  • [6] Gujaral M.L., 1955, J INDIAN MED RES, V43, P637
  • [7] GUPTA RC, 1979, J INDIAN CHEM SOC, V56, P219
  • [8] Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives - Interactions with tubulin
    Hamel, E
    Lin, CM
    Plowman, J
    Wang, HK
    Lee, KH
    Paull, KD
    [J]. BIOCHEMICAL PHARMACOLOGY, 1996, 51 (01) : 53 - 59
  • [9] 6-alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds:: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization
    Hour, MJ
    Huang, LJ
    Kuo, SC
    Xia, Y
    Bastow, K
    Nakanishi, Y
    Hamel, E
    Lee, KH
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (23) : 4479 - 4487
  • [10] KACKER IK, 1951, J INDIAN CHEM SOC, V28, P344
123