Maslinic acid derivatives induce significant apoptosis in bl6f10 murine melanoma cells

被引：44

作者：

Parra, Andres ^{[1
]}

Rivas, Francisco ^{[1
]}

Martin-Fonseca, Samuel ^{[1
]}

Garcia-Granados, Andres ^{[1
]}

Martinez, Antonio ^{[1
]}

机构：

[1] Univ Granada, Fac Ciencias, Dept Quim Organ, E-18071 Granada, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 12期

关键词：

Maslinic acid derivatives; Synthesis; Cytotoxicity; Anticancer activity; Apoptosis; OLIVE-PRESSING RESIDUES; COLON-CANCER CELLS; NF-KAPPA-B; NATURAL TRITERPENE; PENTACYCLIC TRITERPENES; TRIENE SYSTEMS; OLEA-EUROPAEA; A-RING; PRODUCTS; DEGRADATION;

D O I：

10.1016/j.ejmech.2011.10.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Maslinic acid (2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid), a natural dihydroxylated pentacyclic triterpene acid isolated from olive-pressing residues, has been investigated together with some of its derivatives regarding the induction of apoptosis in B16F10 melanoma cells. Some of the compounds tested are described in this work, but others come from previous studies. Ten of these derivatives induce over 80% of apoptosis, clearly promoting cell death in B16F10 melanoma. By contrast, the induction cell death through necrosis was very slightly significant with these compounds. These results indicate that maslinic acid derivatives are promising chemopreventive and chemotherapeutic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：5991 / 6001

页数：11

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