Highly Enantioselective Asymmetric Isomerization of Primary Allylic Alcohols with an Iridium-N,P Complex

被引：54
作者：
Li, Jia-Qi [1 ]
Peters, Byron [1 ]
Andersson, Pher G. [1 ,2 ]
机构：
[1] Uppsala Univ, Dept Biochem & Organ Chem, S-75123 Uppsala, Sweden
[2] Univ KwaZulu Natal, Sch Chem, Durban, South Africa
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 40期
基金：
瑞典研究理事会;
关键词：
aldehydes; allylic alcohols; asymmetric catalysis; iridium; isomerization; N; P ligands; CATALYZED ISOMERIZATION; HYDROGENATION; LIGANDS; OLEFINS;
D O I：
10.1002/chem.201101524
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Access to chiral aldehydes: The asymmetric isomerization of primary allylic alcohols was studied with a bicyclic phosphine-oxazoline iridium catalyst. This method displays a broad substrate scope and leads to the desired chiral aldehydes with excellent enantioselectivities (see scheme; R 1, R 2=Ar or alkyl). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11143 / 11145
页数：3
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