Efficient synthesis of cinacalcet hydrochloride

被引：27

作者：

Bijukumar, Gopinathenpillai ^{[1
]}

Maloyesh, Biswas ^{[1
]}

Bhaskar, Bhirud Shekhar ^{[1
]}

Rajendra, Agarwal ^{[1
]}

机构：

[1] Macleods Pharmaceut Ltd, Ctr Res & Dev, Chem Proc Res & Dev, Bombay 400093, Maharashtra, India

来源：

SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 10期

关键词：

calcimimetics; cinacalcet; Knoevenagel-Doebner condensation;

D O I：

10.1080/00397910801928541

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route to synthesize cinacalcet hydrochloride ((R)-alpha-methyl-N-[3-[3( trifluoromethyl) phenyl] propyl]-1-naphthalene methane amine hydrochloride) has been described. The key steps include the Knoevenagel-Doebner condensation and the amide reduction under milder conditions.

引用

页码：1512 / 1517

页数：6

共 8 条

[1]

ASTON KW, 1994, TETRAHEDRON LETT, V35, P3867

[2] SYNTHESIS OF (ALLYLOXY)METHYL-SUBSTITUTED DIAZA-18-CROWN-6 COMPOUNDS FOR ATTACHMENT TO SILICA-GEL [J].