Silver-Catalyzed Trifluoromethoxylation of Aziridines

被引：18
作者：
Xin, Jingrui [1 ,2 ]
Deng, Xiangyu [1 ,2 ]
Tang, Pingping [1 ,2 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 03期
关键词：
MEDIATED OXIDATIVE TRIFLUOROMETHYLATION; FLUORINE; ETHERS; FLUORODECARBOXYLATION; COMPLEXES; ALCOHOLS; ALKENES; ACCESS; ARENES; WATER;
D O I：
10.1021/acs.orglett.1c04226
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We disclose a silver-catalyzed trifluoromethoxylation of N-tosyl aziridines with trifluoromethyl arylsulfonate. The protocol is characterized by its mild conditions, simple operations, and good chemo- and regioselectivity. In addition, the trifluoromethoxylation of trisubstituted aziridines could construct C-OCF3 quaternary centers exclusively, which is quite rare. This method unlocks a new catalytic blueprint for accessing beta-trifluoromethoxylated amines, which could be important building blocks in synthetic chemistry.
引用
收藏
页码：881 / 885
页数：5
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