Low molecular weight hyaluronan, via AP-1 and NF-κB signalling, induces IL-8 in transformed bronchial epithelial cells

被引：5
|
作者：
Ochoa, Christiaan D.
Garg, Hari G.
Hales, Charles A.
Quinn, Deborah A.
机构：
[1] Massachusetts Gen Hosp, Dept Med, Pulm & Crit Care Unit, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
来源：
SWISS MEDICAL WEEKLY | 2011年 / 141卷
关键词：
low molecular weight hyaluronan; IL-8; AP-1; NF-kappa B; mechanical strain; high tidal volume mechanical ventilation; bronchial epithelium; HYPOXIC PULMONARY-HYPERTENSION; INDUCED LUNG INJURY; MOUSE MACROPHAGES; EXPRESSION; SYNTHASE; KB; INFLAMMATION; VENTILATION; INHIBITION; PRESSURE;
D O I：
10.4414/smw.2011.13255
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
ANOVA: Analysis of Variance; AP-1: Activator Protein-1; BEGM: Bronchial Epithelial Cell Growth System; DNA: deoxyribonucleic acid; ELISA: Enzyme-linked Immunosorbent Assay; GAG: Glucosaminoglycans; HA: Hyaluronan; HAdase: Hyaluronydase; HAS: Hyaluronan Synthase; HMW-HA: High Molecular Weight Hyaluronan; IFN: Interferon; IL-8: Interleukin-8; JNK: c-Jun NH2-terminal Kinase; ERK 1/2: Extracellular Signal-regulated Kinase 1/2; JAK/STAT pathway: Janus Kinase/Signal Transducers and Activator of Transcription pathway; LDH: Lactate dehydrogenase; LMW-HA: Low Molecular Weight Hyaluronan; NF-kappa B: Nuclear Factor kappa-light-chain-enhancer of activated B cells; MAPK: Mitogen-activated Protein Kinase; TLR: Toll-like Receptors; TNF: Tumour Necrosis Factor; VALI: Ventilator-associated Lung Injury.
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页数：11
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