Low molecular weight hyaluronan, via AP-1 and NF-κB signalling, induces IL-8 in transformed bronchial epithelial cells

被引：6

作者：

Ochoa, Christiaan D.

Garg, Hari G.

Hales, Charles A.

Quinn, Deborah A.

机构：

[1] Massachusetts Gen Hosp, Dept Med, Pulm & Crit Care Unit, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

SWISS MEDICAL WEEKLY | 2011年 / 141卷

关键词：

low molecular weight hyaluronan; IL-8; AP-1; NF-kappa B; mechanical strain; high tidal volume mechanical ventilation; bronchial epithelium; HYPOXIC PULMONARY-HYPERTENSION; INDUCED LUNG INJURY; MOUSE MACROPHAGES; EXPRESSION; SYNTHASE; KB; INFLAMMATION; VENTILATION; INHIBITION; PRESSURE;

D O I：

10.4414/smw.2011.13255

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ANOVA: Analysis of Variance; AP-1: Activator Protein-1; BEGM: Bronchial Epithelial Cell Growth System; DNA: deoxyribonucleic acid; ELISA: Enzyme-linked Immunosorbent Assay; GAG: Glucosaminoglycans; HA: Hyaluronan; HAdase: Hyaluronydase; HAS: Hyaluronan Synthase; HMW-HA: High Molecular Weight Hyaluronan; IFN: Interferon; IL-8: Interleukin-8; JNK: c-Jun NH2-terminal Kinase; ERK 1/2: Extracellular Signal-regulated Kinase 1/2; JAK/STAT pathway: Janus Kinase/Signal Transducers and Activator of Transcription pathway; LDH: Lactate dehydrogenase; LMW-HA: Low Molecular Weight Hyaluronan; NF-kappa B: Nuclear Factor kappa-light-chain-enhancer of activated B cells; MAPK: Mitogen-activated Protein Kinase; TLR: Toll-like Receptors; TNF: Tumour Necrosis Factor; VALI: Ventilator-associated Lung Injury.

引用

页数：11

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