Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization

被引：24
作者：
Higashi, H
Chen, NH
机构：
[1] Mitsubishi Kagaku Inst Life Sci, Tokyo 1948511, Japan
[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
GLYCOCONJUGATE JOURNAL | 2003年 / 20卷 / 01期
关键词：
ganglioside; CaMKII; A-kinase; N-acetylgalactosamine; dendritogenesis;
D O I：
10.1023/B:GLYC.0000016742.88750.1a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exposure of neuronal cells to nanomolar concentrations of oligosaccharide portions of ganglioside GM2 and GT1b stimulates cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin-dependent protein kinase II ( CaMKII), respectively, in a few seconds suggesting the presence of glyco-receptor-like molecules on the surface of the cells. Both GM2/PKA (GalNAc/PKA) and GT1b/CaMKII signaling cascades induced cytoskeletal actin reorganization through Cdc42 activation leading to filopodia formation within 2 min. Long-term effects of these glyco-signals were facilitation of dendritic differentiation of primary cultured hippocampal neurons and cerebellar Purkinje neurons indicating physiological roles of the signals in neuronal differentiation and maturation.
引用
收藏
页码：49 / 58
页数：10
相关论文
共 88 条
[1]   STIMULATION OF CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDENT PROTEIN-KINASE WITH BRAIN GANGLIOSIDES [J].
ARAKANE, F ;
FUKUNAGA, K ;
SATAKE, M ;
MIYAZAKI, K ;
OKAMURA, H ;
MIYAMOTO, E .
NEUROCHEMISTRY INTERNATIONAL, 1995, 26 (02) :187-193
[2]  
BASU S C, 1991, Glycobiology, V1, P469, DOI 10.1093/glycob/1.5.469
[3]   Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region [J].
Blitzer, RD ;
Wong, T ;
Nouranifar, R ;
Iyengar, R ;
Landau, EM .
NEURON, 1995, 15 (06) :1403-1414
[4]   IMMUNOCYTOCHEMICAL LOCALIZATION OF ACTIN AND MICROTUBULE-ASSOCIATED PROTEIN MAP2 IN DENDRITIC SPINES [J].
CACERES, A ;
PAYNE, MR ;
BINDER, LI ;
STEWARD, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (06) :1738-1742
[5]   Extracellular carbohydrate-signal triggering cAMP-dependent protein kinase-dependent neuronal actin-reorganization [J].
Chen, N ;
Furuya, S ;
Shinoda, Y ;
Yumoto, M ;
Ohtake, A ;
Sato, K ;
Doi, H ;
Hashimoto, Y ;
Kudo, Y ;
Higashi, H .
NEUROSCIENCE, 2003, 122 (04) :985-995
[6]   Ganglioside/calmodulin kinase II signal inducing cdc42-mediated neuronal actin reorganization [J].
Chen, N ;
Furuya, S ;
Doi, H ;
Hashimoto, Y ;
Kudo, Y ;
Higashi, H .
NEUROSCIENCE, 2003, 120 (01) :163-176
[7]   Dendritic spine changes associated with hippocampal long-term synaptic plasticity [J].
Engert, F ;
Bonhoeffer, T .
NATURE, 1999, 399 (6731) :66-70
[8]   Cyclic AMP and protein kinase a stimulate Cdc42:: Role of A2 adenosine receptors in human mast cells [J].
Feoktistov, I ;
Goldstein, AE ;
Biaggioni, I .
MOLECULAR PHARMACOLOGY, 2000, 58 (05) :903-910
[9]   Rapid actin-based plasticity in dendritic spines [J].
Fischer, M ;
Kaech, S ;
Knutti, D ;
Matus, A .
NEURON, 1998, 20 (05) :847-854
[10]   AXONAL TRANSPORT OF GANGLIOSIDES IN GOLDFISH OPTIC-NERVE [J].
FORMAN, DS ;
LEDEEN, RW .
SCIENCE, 1972, 177 (4049) :630-&
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