Molecular epidemiology of mumps virus strains circulating in south-west China from 2007 to 2009

被引:0
作者
Shi, Haijing [1 ]
Liu, Longding [1 ]
Ma, Shaohui [1 ]
Chen, Junying [1 ]
Che, Yanchun [1 ]
Wang, Jingjing [1 ]
Li, Qihan [1 ]
机构
[1] Chinese Acad Med Sci, Inst Med Biol, Kunming 650118, Peoples R China
关键词
SH GENE; MEASLES; VACCINE; IDENTIFICATION; PANCREATITIS; GENOTYPE; SEQUENCE;
D O I
10.1099/mm.0.021907-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The genetic characteristics of mumps virus (MuV) strains isolated from sporadic mumps cases between 2007 and 2009 in three provinces of south-west China were investigated. MuV detection was carried out by nested RT-PCR on 117 cases. The small hydrophobic gene of 33 isolated strains was identified, and sequence analysis revealed that all the isolates belonged to the lineage genotype F with slight nucleotide variation. Furthermore, the virus haemagglutinin-neuraminidase and nucleoprotein antigens exhibited a high degree of nucleotide and amino acid similarity (>99%) within all isolates, whilst the fusion protein appeared to have certain geographical differences. This study on molecular surveillance will help to monitor the circulation of MuV in China.
引用
收藏
页码:1496 / 1501
页数:6
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