Tumor-associated stromal cells as key contributors to the tumor microenvironment

被引:583
作者
Bussard, Karen M. [1 ,2 ]
Mutkus, Lysette [3 ]
Stumpf, Kristina [3 ]
Gomez-Manzano, Candelaria [4 ]
Marini, Frank C. [1 ,3 ]
机构
[1] Wake Forest Comprehens Canc Ctr, Dept Canc Biol, Winston Salem, NC 27157 USA
[2] Thomas Jefferson Univ, Dept Canc Biol, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA
[3] Wake Forest Univ, Dept Regenerat Med, Winston Salem, NC 27157 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA
来源
BREAST CANCER RESEARCH | 2016年 / 18卷
关键词
Tumor-associated fibroblast; Cancer-associated fibroblast; Mesenchymal stem cell; Myofibroblast; Stroma; Tumor microenvironment; Tumor-associated stroma; Alpha-smooth muscle actin; microRNA; Exosome; IL-6; MCP-1; CANCER-ASSOCIATED FIBROBLASTS; MICRORNAS; EXOSOMES; METASTASIS; TRANSITION; ADIPOCYTES; PHENOTYPE; RECRUITMENT; ACTIVATION; REGULATORS;
D O I
10.1186/s13058-016-0740-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The tumor microenvironment is a heterogeneous population of cells consisting of the tumor bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are recruited by cancer cells from nearby endogenous host stroma and promote events such as tumor angiogenesis, proliferation, invasion, and metastasis, as well as mediate mechanisms of therapeutic resistance. In addition, recruited stromal cells range in type and include vascular endothelial cells, pericytes, adipocytes, fibroblasts, and bone-marrow mesenchymal stromal cells. During normal wound healing and inflammatory processes, local stromal cells change their phenotype to become that of reactive stroma. Under certain conditions, however, tumor cells can co-opt these reactive stromal cells and further transition them into tumor-associated stromal cells (TASCs). These TASCs express higher levels of proteins, including alpha-smooth muscle actin, fibroblast activating protein, and matrix metalloproteinases, compared with their normal, non-reactive counterparts. TASCs are also known to secrete many pro-tumorigenic factors, including IL-6, IL-8, stromal-derived factor-1 alpha, vascular endothelial growth factor, tenascin-C, and matrix metalloproteinases, among others, which recruit additional tumor and pro-tumorigenic cells to the developing microenvironment. Here, we review the current literature pertaining to the origins of recruited host stroma, contributions toward tumor progression, tumor-associated stromal cells, and mechanisms of crosstalk between endogenous host stroma and tumor cells.
引用
收藏
页数:11
相关论文
共 58 条
[1]   A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis [J].
Acharyya, Swarnali ;
Oskarsson, Thordur ;
Vanharanta, Sakari ;
Malladi, Srinivas ;
Kim, Juliet ;
Morris, Patrick G. ;
Manova-Todorova, Katia ;
Leversha, Margaret ;
Hogg, Nancy ;
Seshan, Venkatraman E. ;
Norton, Larry ;
Brogi, Edi ;
Massague, Joan .
CELL, 2012, 150 (01) :165-178
[2]  
Ali S, 2015, AM J CANCER RES, V5, P1251
[3]  
[Anonymous], MERR WEBST DICT
[4]   Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment [J].
Augsten, Martin .
FRONTIERS IN ONCOLOGY, 2014, 4
[5]   A Think Tank of TINK/TANKs: Tumor-Infiltrating/Tumor-Associated Natural Killer Cells in Tumor Progression and Angiogenesis [J].
Bruno, Antonino ;
Ferlazzo, Guido ;
Albini, Adriana ;
Noonan, Douglas M. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (08)
[6]   The Proangiogenic Phenotype of Natural Killer Cells in Patients with Non-Small Cell Lung Cancer [J].
Bruno, Antonino ;
Focaccetti, Chiara ;
Pagani, Arianna ;
Imperatori, Andrea S. ;
Spagnoletti, Marco ;
Rotolo, Nicola ;
Cantelmo, Anna Rita ;
Franzi, Francesca ;
Capella, Carlo ;
Ferlazzo, Guido ;
Mortara, Lorenzo ;
Albini, Adriana ;
Noonan, Douglas M. .
NEOPLASIA, 2013, 15 (02) :133-U191
[7]   Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach [J].
Cerasuolo, Marianna ;
Paris, Debora ;
Iannotti, Fabio A. ;
Melck, Dominique ;
Verde, Roberta ;
Mazzarella, Enrico ;
Motta, Andrea ;
Ligresti, Alessia .
CANCER RESEARCH, 2015, 75 (15) :2975-2986
[8]   Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats [J].
Chen, Haw-Wen ;
Huang, Chin-Shiu ;
Li, Chien-Chun ;
Lin, Ai-Hsuan ;
Huang, Yu-Ju ;
Wang, Tsu-Shing ;
Yao, Hsien-Tsung ;
Lii, Chong-Kuei .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2014, 280 (01) :1-9
[9]  
Cirri P, 2011, AM J CANCER RES, V1, P482
[10]   Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival [J].
Curiel, TJ ;
Coukos, G ;
Zou, LH ;
Alvarez, X ;
Cheng, P ;
Mottram, P ;
Evdemon-Hogan, M ;
Conejo-Garcia, JR ;
Zhang, L ;
Burow, M ;
Zhu, Y ;
Wei, S ;
Kryczek, I ;
Daniel, B ;
Gordon, A ;
Myers, L ;
Lackner, A ;
Disis, ML ;
Knutson, KL ;
Chen, LP ;
Zou, WP .
NATURE MEDICINE, 2004, 10 (09) :942-949