Age-related change of somatostatin-immunoreactive neurones in the main olfactory bulb of the rat

被引：7

作者：

Hwang, IK ^{[1
]}

Lee, JC ^{[1
]}

Park, SK ^{[1
]}

An, SJ ^{[1
]}

Lee, HY ^{[1
]}

Lee, YB ^{[1
]}

Sohn, HS ^{[1
]}

Lee, IS ^{[1
]}

Kang, TC ^{[1
]}

Won, MH ^{[1
]}

机构：

[1] Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, South Korea

来源：

ANATOMIA HISTOLOGIA EMBRYOLOGIA | 2004年 / 33卷 / 01期

关键词：

D O I：

10.1046/j.1439-0264.2003.00515.x

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Somatostatin is found in the olfactory system, including the main olfactory bulb (MOB), and is thought to be one of the neuroactive substances for olfaction. However, somatostatin immunoreactivity in the olfactory system has not been determined during ageing. Hence, we examined the age-related changes of somatostatin-immunoreactive (IR) neurones in the rat MOB over a period of 2 years, at the following various ageing stages: post-natal month I (PM 1), PM 3, PM 6, PM 12 and PM 24. In PM 1 group, a few somatostatin-IR neurones were detected in the granule cell layer (GCL), and had slender or oval somata and short processes. At PM 3, somatostatin-IR neurones were observed in the glomerular, external plexiform and GCL. The size of somatostatin-IR somata was larger than that at PM 1. In PM 6 group, the number and size of somatostatin-IR neurones increased, and their processes became longer While running in various directions. At PM 12, somatostatin-IR neurones increased in number, and their processes became markedly longer than those at PM 6. At this stage, somatostatin-IR neurones had multipolar somata, and were the largest in size. In PM 24 group, somatostatin-IR neurones were most numerous. However, the processes of somatostatin-IR neurones were shorter than those at PM 12. This study suggests that the increased number of somatostatin-IR neurones in the MOB of aged rats may play a role to compensate for any decrease of olfactory function.

引用

页码：59 / 63

页数：5