The Impact of Chemical Probes in Drug Discovery: A Pharmaceutical Industry Perspective

被引：56

作者：

Garbaccio, Robert M. ^{[1
]}

Parmee, Emma R. ^{[1
]}

机构：

[1] Merck Res Labs, Global Chem, Mailstop 14-2,740 Sumneytown Pike, West Point, PA 19486 USA

来源：

CELL CHEMICAL BIOLOGY | 2016年 / 23卷 / 01期

关键词：

SMALL-MOLECULE INHIBITORS; PEPTIDASE-IV INHIBITOR; RECEPTOR; TARGET; ANTAGONIST; POTENT; CELLS; AKT; REPLICATION; MK-0657;

D O I：

10.1016/j.chembiol.2015.11.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical probes represent an important component of both academic and pharmaceutical drug discovery research. As a complement to prior reviews that have defined this scientific field, we aim to provide an industry perspective on the value of having high-quality chemical probes throughout the course of preclinical research. By studying examples from the internal Merck pipeline, we recognize that these probes require significant collaborative investment to realize their potential impact in clarifying the tractability and translation of a given therapeutic target. This perspective concludes with recommendations for chemical probe discovery aimed toward maximizing their potential to identify targets that result in the successful delivery of novel therapeutics.

引用

页码：10 / 17

页数：8

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