A multi-strain probiotic blend reshaped obesity-related gut dysbiosis and improved lipid metabolism in obese children

被引:26
|
作者
Chen, An-Chyi [1 ,2 ]
Fang, Tzu-Jung [3 ,4 ]
Ho, Hsieh-Hsun [5 ]
Chen, Jui-Fen [5 ]
Kuo, Yi-Wei [5 ]
Huang, Yen-Yu [5 ]
Tsai, Shin-Yu [5 ]
Wu, Shu-Fen [1 ,2 ]
Lin, Hung-Chih [6 ,7 ,8 ]
Yeh, Yao-Tsung [9 ,10 ]
机构
[1] China Med Univ, Div Pediat Gastroenterol, Childrens Hosp, Taichung, Taiwan
[2] China Med Univ, Sch Med, Taichung, Taiwan
[3] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan
[4] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Geriatr & Gerontol, Kaohsiung, Taiwan
[5] Glac Biotech Co Ltd, Dept Res & Design, Tainan, Taiwan
[6] China Med Univ, Div Neonatol, Childrens Hosp, Taichung, Taiwan
[7] China Med Univ, Sch Chinese Med, Taichung, Taiwan
[8] Asia Univ, Asia Univ Hosp, Taichung, Taiwan
[9] Fooyin Univ, Aging & Dis Prevent Res Ctr, Kaohsiung, Taiwan
[10] Fooyin Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan
来源
FRONTIERS IN NUTRITION | 2022年 / 9卷
关键词
childhood obesity; probiotics; gut microbiota; high-density lipoprotein (HDL); adiponectin; PHYSICAL-ACTIVITY; OVERWEIGHT; MICROBIOTA; WEIGHT; INFLAMMATION; ADIPOKINES; PROFILE;
D O I
10.3389/fnut.2022.922993
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background and aimsObese children are more prone to becoming obese adults, and excess adiposity consequently increases the risk of many complications, such as metabolic syndromes, non-alcoholic fatty liver disease, cardiovascular disease, etc. This study aimed to evaluate the effects of multi-strain probiotics on the gut microbiota and weight control in obese children. MethodsA double-blind, randomized, placebo-controlled trial was carried out on overweight and obese children. Subjects received 12 weeks of treatment with supplementary probiotics that contained three strains: Lactobacillus salivarius AP-32, L. rhamnosus bv-77, and Bifidobacterium animalis CP-9, plus diet and exercise guidance. A total of 82 children were enrolled, and 53 children completed the study. ResultsThe supplementation of multi-strain probiotics resulted in a significant effect demonstrating high-density lipoprotein (HDL) and adiponectin elevation. At the same time, body mass index (BMI) and serum total cholesterol, low-density lipoprotein (LDL), leptin, and tumor necrosis factor-alpha (TNF-alpha) levels were reduced. Lactobacillus spp. and B. animalis were particularly increased in subjects who received probiotic supplements. The abundance of Lactobacillus spp. was inversely correlated with the ether lipid metabolism pathway, while that of B. animalis was positively correlated with serum adiponectin levels. ConclusionOur results show that obesity-related gut dysbiosis can be reshaped by the supplementation of a multi-strain probiotic to improve lipid metabolism. The regular administration of a multi-strain probiotic supplement may be helpful for weight control and health management in overweight and obese children.
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页数:15
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