Secolignans, Neolignans and Phenylpropanoids from Daphne feddei and Their Biological Activities

被引：0
|
作者：
Hu, Qiu-Fen [1 ,2 ,3 ]
Mu, Huai-Xue [1 ,2 ]
Huang, Hai-Tao [4 ]
Lv, Hua-Ying [3 ]
Li, Shu-Li [3 ]
Tu, Pen-Fei [3 ]
Li, Gan-Peng [1 ,2 ]
机构：
[1] Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
[2] Minist Educ, Kunming 650031, Peoples R China
[3] Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
[4] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 11期
关键词：
Daphne feddei; secolignan; neolignan; anti-human immunodeficiency virus-1 activity; cytotoxicity; INHIBITORY-ACTIVITIES; CYTOTOXICITY; CONSTITUENTS; GLYCOSIDES; ACID;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new secolignans and one new neolignan, named feddeiphenols A-C (1-3), together with eight known compounds (4-11), were isolated from the leaves and stems of Daphne feddei. Their structures were established on the base of spectroscopic methods, mainly extensive NMR, UV spectroscopy, and MS spectrometry. Compounds 1-11 were tested for their anti-human immunodeficiency virus (HIV)-1 activity and cytotoxicity. The results revealed that compounds 1, 2, 3, 7, and 9 showed therapeutic index (TI) values above 30, respectively, and the other compounds also showed weak anti-HIV-1 activity. Compound I showed modest cytotoxic activity. The other compounds also showed weak cytotoxic activity.
引用
收藏
页码：1421 / 1424
页数：4
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