Effect of Pamamycin-607 on Secondary Metabolite Production by Streptomyces spp.

被引：11
|
作者：
Hashimoto, Makoto [2 ]
Katsura, Hirotaka [3 ]
Kato, Risako [3 ]
Kawaide, Hiroshi [1 ]
Natsume, Masahiro [1 ]
机构：
[1] Tokyo Univ Agr & Technol, Inst Agr, Div Bioregulat & Biointeract, Fuchu, Tokyo 1838509, Japan
[2] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Dept Plant Prod, Fuchu, Tokyo 1838509, Japan
[3] Tokyo Univ Agr & Technol, Dept Bioregulat & Biointeract, Grad Sch Agr, Fuchu, Tokyo 1838509, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2011年 / 75卷 / 09期
关键词：
pamamycin-607; aerial mycelium formation; secondary metabolite production; antibiotic; Streptomyces alboniger; MYCELIUM-INDUCING SUBSTANCE; ANTHRACYCLINE ANTIBIOTICS; BIOLOGICAL-ACTIVITY; A-FACTOR; ALBONIGER; SPECTROMETRY;
D O I：
10.1271/bbb.110251
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of the aerial mycelium-inducing compound, pamamycin-607, on antibiotic production by several Streptomyces spp. was examined. Exposure to 6.6 mu m pamamycin-607 stimulated by 2.7 fold the puromycin production by Streptomyces alboniger NBRC 12738, in which pamamycin-607 had first been isolated, and restored aerial mycelium formation. Pamamycin-607 also stimulated the respective production of streptomycin by S. griseus NBRC 12875 and that of cinerubins A and B by S. tauricus JCM 4837 by approximately 1.5, 1.7 and 1.9 fold. The antibiotic produced by Streptomyces sp. 91-a was identified as virginiamycin M-1, and its synthesis was enhanced 2.6 fold by pamamycin-607. These results demonstrate that pamamycin-607 not only restored or stimulated aerial mycelium formation, but also stimulated secondary metabolite production.
引用
收藏
页码：1722 / 1726
页数：5
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