Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-Oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?

被引：17

作者：

Carosso, Andrea Roberto ^{[1
]}

van Eekelen, Rik ^{[2
]}

Revelli, Alberto ^{[1
]}

Canosa, Stefano ^{[1
]}

Mercaldo, Noemi ^{[1
]}

Benedetto, Chiara ^{[1
]}

Gennarelli, Gianluca ^{[1
]}

机构：

[1] Univ Torino, St Anna Hosp, Obstet & Gynecol 1U, Physiopathol Reprod & IVF Unit,Hlth & Sci City, Via Ventimiglia 3, I-10126 Turin, Italy

[2] Amsterdam UMC, Acad Med Ctr, Ctr Reprod Med, NL-1105 AZ Amsterdam, Netherlands

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 03期

关键词：

IVF; unexplained infertility; follicular output rate; follicle-oocyte index; ovarian sensitivity index; ovarian responsiveness; live birth; ANTI-MULLERIAN HORMONE; IN-VITRO FERTILIZATION; RATE FORT; RESERVE; IVF/ICSI; POOR; FSH; GONADOTROPIN; STIMULATION; NOMOGRAM;

D O I：

10.3390/jcm11030859

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

(1) Background: Several researchers have investigated alternative markers related to ovarian responsiveness in order to better predict IVF outcomes, particularly in advanced reproductive-aged women. The follicular output rate (FORT), the follicle-oocyte index (FOI) and the ovarian sensitivity index (OSI) are among the most promising. However, these three metrics have not been investigated as independent predictors of live birth in women of advanced reproductive age; neither have they been compared to the two 'component' characteristics that are used to calculate them. (2) Methods: A logistic regression model containing all relevant predictors of ovarian reserve or response was used to evaluate the potential of FORT, FOI and OSI as predictors of live birth. After, the non-linear associations between FORT, FOI and OSI and the probability of live birth were evaluated. Finally, we fitted multiple logistic regression models to compare whether FORT, FOI and OSI were more informative predictors than their components. (3) Results: 590 couples received a total of 740 IVF cycles, after which, 127 (17.5%) obtained a live birth. None of FORT, FOI and OSI showed a strength of association or a p-value even close to female age (odds ratio for live birth (95% confidence interval) 1.00 (0.99-1.01), 1.00 (0.99-1.01), 0.98 (0.88-1.11) and 0.58 (0.48-0.72), respectively). The three models comparing FORT, FOI and OSI with the number of oocytes retrieved, the AFC, the number of preovulatory follicles and the FSH total dose were not more informative. (4) Conclusions: In a population of women of advanced age with unexplained infertility, none of FORT, FOI and OSI were predictive of live birth or more predictive than the two 'component' characteristics that were used to calculate them. We suggest clinicians and researchers still use female age as the most reliable predictor of an IVF treatment.

引用

页数：11

共 37 条

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