Determination of triclosan in antiperspirant gels by first-order derivative spectrophotometry

被引：7
作者：
Du, Lina [2 ]
Li, Miao [2 ]
Jin, Yiguang [1 ,2 ]
机构：
[1] Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
[2] Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
来源：
PHARMAZIE | 2011年 / 66卷 / 10期
关键词：
MASS-SPECTROMETRY; CARE PRODUCTS; WATER;
D O I：
10.1691/ph.2011.1037
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A first-order derivative UV spectrophotometric method was developed to determine triclosan, a broad-spectrum antimicrobial agent, in health care products containing fragrances which could interfere the determination as impurities. Different extraction methods were compared. Triclosan was extracted with chloroform and diluted with ethanol followed by the derivative spectrophotometric measurement. The interference of fragrances was completely eliminated. The calibration graph was found to be linear in the range of 7.5-45 mu g.mL(-1). The method is simple, rapid, sensitive and proper to determine triclosan in fragrance-containing health care products.
引用
收藏
页码：740 / 743
页数：4
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