Improvement of non-motor and motor behavioral alterations associated with Parkinson-like disease in Drosophila melanogaster: Comparative effects of treatments with hesperidin and L-dopa

被引：14

作者：

Poetini, Maria Rosula ^{[1
]}

Elize, Aparecida Santos Musachio ^{[1
]}

Stifani, Machado Araujo ^{[1
]}

Vandreza, Cardoso Bortolotto ^{[1
]}

Luana, Barreto Meichtry ^{[1
]}

Neici, C. Prime Aceres Silva ^{[1
]}

Dieniffer, Espinosa Janner ^{[1
]}

Diogo, La Rosa Novo ^{[3
]}

Marcia, Foster Mesko ^{[3
]}

Rafael, Roehrs ^{[4
]}

Ramborger, Bruna Piaia ^{[4
]}

Prigol, Marina ^{[1
,2
,5
]}

机构：

[1] Univ Fed Pampa UNIPAMPA, Lab Avaliac Farm & Toxicol Aplicadas Mol, Campus Itaqui, Rua Joaquim Sa Britto,S-N Bairro Pr, BR-97650000 Rio Grande Do Sul, Brazil

[2] Univ Fed Pampa UNIPAMPA, Dept Nutr, Campus Itaqui Rua Joaquim Sa Britto,S-N,Bairro Pr, BR-97650000 Rio Grande Do Sul, Brazil

[3] Univ Fed Pelotas, Centro Ciencias Quim, Farm Alimentos, Campus Univ,S-N Predio Bloco 30 32 Capaco do Leao, BR-96160000 Rio Grande Do Sul, Brazil

[4] Univ Fed Pampa, Programa PosGrad Bioquim PPGBioq, Campus Uruguaiana, BR-472 Km 7, BR-97500970 Uruguaiana, RS, Brazil

[5] Univ Fed Pampa, Campus Itaqui, Rua Luiz Joaquim Sa Britto,S-N Bairro Promorar It, BR-97650000 Rio Grande Do Sul, Brazil

来源：

NEUROTOXICOLOGY | 2022年 / 89卷

关键词：

Behavior; Anxiety; Memory; Drosophila melanogaster; Parkinson's disease; OXIDATIVE STRESS; LIFE-SPAN; MODEL; OCTOPAMINE; EXPOSURE; PROTEIN; RATS; IRON;

D O I：

10.1016/j.neuro.2022.02.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Non-motor alterations such as anxiety and memory deficit may represent early indications of Parkinson's disease (PD), and therapeutic strategies that reduce non-motor alterations are promising alternatives for the treatment. Therefore, the search for natural compounds that act on motor and non-motor complications is highly relevant. In this sense, we demonstrated the role of hesperidin (Hsd) as a citrus flavonoid and its pharmacological properties as an antioxidant and neuroprotective agent. Our objective was to evaluate Hsd in developing motor and non-motor alterations in a Drosophila melanogaster model of Parkinson-like disease induced by iron (Fe) exposure. The flies were divided into six groups: control, Hsd (10 mu M), L-dopa (positive control, 1 mM), Fe (1 mM), Fe + Hsd, and Fe + L-dopa. Motor coordination tests, memory assessment through aversive phototaxy, and anxiety-like behaviors characterized in flies, such as grooming and aggressiveness, were performed. The Hsd attenuated motor and non-motor alterations, such as motor coordination, memory deficits and anxiety-like behaviors, attenuated monoaminergic deficits, and lowered Fe levels in the head of flies. In addition, Hsd prolonged the life of the flies, thereby standing out from the L-dopa-treated group. Thus, Hsd can protect the dopaminergic system from insults caused by Fe, preventing non-motor alterations in PD; Hsd also reduced Fe levels in the flies' heads, suggesting that iron chelation may represent an important mechanism of action, in addition to its antioxidant action.

引用

页码：174 / 183

页数：10

共 71 条

[31] Chemistry and pharmacology of the Citrus bioflavonoid hesperidin [J].