Genetic and epigenetic studies in non-syndromic oral clefts

被引：23
作者：
Alade, Azeez [1 ,2 ,3 ]
Awotoye, Waheed [1 ,2 ]
Butali, Azeez [1 ,2 ]
机构：
[1] Univ Iowa, Coll Dent, Dept Oral Pathol Radiol & Med, Iowa City, IA 52242 USA
[2] Univ Iowa, Iowa Inst Oral Hlth Res, Iowa City, IA USA
[3] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA
来源：
ORAL DISEASES | 2022年 / 28卷 / 05期
关键词：
epigenetics; genetics; Non-syndromic clefts; GENOME-WIDE ASSOCIATION; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; GROWTH-FACTOR-ALPHA; OROFACIAL CLEFTS; CANDIDATE GENES; LINKAGE ANALYSIS; COMMON MUTATION; RARE VARIANTS; MSX1; MUTATION; RISK-FACTOR;
D O I：
10.1111/odi.14146
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The etiology of non-syndromic oral clefts (NSOFC) is complex with genetics, genomics, epigenetics, and stochastics factors playing a role. Several approaches have been applied to understand the etiology of non-syndromic oral clefts. These include linkage, candidate gene association studies, genome-wide association studies, whole-genome sequencing, copy number variations, and epigenetics. In this review, we shared these approaches, genes, and loci reported in some studies.
引用
收藏
页码：1339 / 1350
页数：12
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