Comparison of FDG PET/CT and Bone Marrow Biopsy Results in Patients with Diffuse Large B Cell Lymphoma with Subgroup Analysis of PET Radiomics

被引：15

作者：

Han, Eun Ji ^{[1
]}

Hyun, O. Joo ^{[2
]}

Yoon, Hyukjin ^{[3
]}

Ha, Seunggyun

Yoo, Ie Ryung ^{[2
]}

Min, Jae Won ^{[2
]}

Choi, Joon-Il ^{[4
]}

Choi, Byung-Ock ^{[5
]}

Park, Gyeongsin ^{[6
]}

Lee, Han Hee ^{[7
]}

Jeon, Young-Woo ^{[8
]}

Min, Gi-June ^{[9
]}

Cho, Seok-Goo ^{[9
]}

机构：

[1] Catholic Univ Korea, Coll Med, Yeouido St Marys Hosp, Dept Radiol,Div Nucl Med, Seoul 06591, South Korea

[2] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Radiol,Div Nucl Med, Seoul 06591, South Korea

[3] Catholic Univ Korea, Coll Med, St Vincents Hosp, Dept Radiol,Div Nucl Med, Seoul 06591, South Korea

[4] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Radiol, Seoul 06591, South Korea

[5] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Radiat Oncol, Seoul 06591, South Korea

[6] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Hosp Pathol, Seoul 06591, South Korea

[7] Catholic Univ Korea, Coll Med, Yeouido St Marys Hosp, Dept Gastroenterol, Seoul 06591, South Korea

[8] Catholic Univ Korea, Coll Med, Yeouido St Marys Hosp, Dept Hematol, Seoul 06591, South Korea

[9] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Hematol, Seoul 06591, South Korea

来源：

DIAGNOSTICS | 2022年 / 12卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

diffuse large B cell lymphoma; FDG; PET; CT; radiomics; NON-HODGKINS-LYMPHOMA; F-18-FDG PET/CT; DIAGNOSTIC PERFORMANCE; CLINICAL-SIGNIFICANCE; INVOLVEMENT; INFILTRATION; DISCORDANCE; PROVIDES; DISEASE;

D O I：

10.3390/diagnostics12010222

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Whether FDG PET/CT can replace bone marrow biopsy (BMBx) is undecided in patients with diffuse large B cell lymphoma (DLBCL). We compared the visual PET findings and PET radiomic features, with BMBx results. A total of 328 patients were included; 269 (82%) were PET-negative and 59 (18%) were PET-positive for bone lesions on visual assessment. A fair degree of agreement was present between PET and BMBx findings (kappa = 0.362, p < 0.001). Bone involvement on PET/CT lead to stage IV in 12 patients, despite no other evidence of extranodal lesion. Of 35 discordant PET-positive and BMBx-negative cases, 22 (63%) had discrete bone uptake on PET/CT. A total of 144 patients were eligible for radiomic analysis, and two grey-level zone-length matrix derived parameters obtained from the iliac crests showed a trend for higher values in the BMBx-positive group compared to the BMBx-negative group (mean 436.6 +/- 449.0 versus 227.2 +/- 137.8, unadjusted p = 0.037 for high grey-level zone emphasis; mean 308.8 +/- 394.4 versus 135.7 +/- 97.2, unadjusted p = 0.048 for short-zone high grey-level emphasis), but statistical significance was not found after multiple comparison correction. Visual FDG PET/CT assessment and BMBx results were discordant in 17% of patients with newly diagnosed DLBCL, and the two tests are complementary in the evaluation of bone involvement.

引用

页数：11

共 40 条

[1] Systematic review and meta-analysis on the diagnostic performance of FDG-PET/CT in detecting bone marrow involvement in newly diagnosed Hodgkin lymphoma: is bone marrow biopsy still necessary? [J].