Coronavirus disease 2019 (COVID-19): a clinical update

被引：276
作者：
Zhou, Min [1 ,2 ,3 ]
Zhang, Xinxin [1 ,4 ,5 ]
Qu, Jieming [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Natl Res Ctr Translat Med, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Resp & Crit Care Med, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Inst Resp Dis, Sch Med, Shanghai 200025, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Res Lab Clin Virol, Shanghai 200025, Peoples R China
[5] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp North, Shanghai 200025, Peoples R China
来源：
FRONTIERS OF MEDICINE | 2020年 / 14卷 / 02期
关键词：
coronavirus disease 2019; epidemiology; pathology; radiology; clinical characteristics; treatment; SARS; GUIDELINES; DIAGNOSIS; EVOLUTION; WUHAN;
D O I：
10.1007/s11684-020-0767-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.
引用
收藏
页码：126 / 135
页数：10
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