Virulence mechanisms and Cryptococcus neoformans pathogenesis

被引：89

作者：

Alspaugh, J. Andrew ^{[1
]}

机构：

[1] Duke Univ, Sch Med, Dept Mol Genet & Microbiol, Dept Med, Durham, NC 27710 USA

来源：

FUNGAL GENETICS AND BIOLOGY | 2015年 / 78卷

基金：

美国国家卫生研究院;

关键词：

Microbial pathogenesis; Virulence factor; Mycoses; Fungal infection; EXTRACELLULAR VESICLES; CAPSULE; PROTEIN; CHITOSAN; GROWTH; CHITIN;

D O I：

10.1016/j.fgb.2014.09.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human fungal pathogen Cryptococcus neoformans is able to rapidly and effectively adapt to varying conditions, favoring its survival in the environment and in the infected host. Many microbial phenotypes have been specifically correlated with virulence in this opportunistic pathogen, such as capsule production, melanin formation, and the secretion of various proteins. Additionally, cellular features such as the cell wall and morphogenesis play important roles in the interaction of this fungus with host immune recognition and response pathways. Survival in the face of host stress also requires maintaining RNA/DNA integrity. Additionally, aging and senescence of the fungal cells determines resistance to \host-derived\ stresses. New mechanisms regulating the expression of these \virulence-associated\ phenotypes have been recently explored. Importantly, human clinical studies are now confirming the roles of specific microbial factors in human infections. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：55 / 58

页数：4

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