Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) rnonomethyl ether-block-poly(acrylic acid)-block-poly (N-isopropylacrylamide) copolymer to form micelles for drug delivery

被引：23
作者：
He, Xiaohua [1 ]
Wu, Xiaomeng [1 ]
Gao, Chunyan [1 ]
Wang, Kai [1 ]
Lin, Shaoliang [2 ]
Huang, Wei [1 ]
Xie, Meiran [1 ]
Yan, Deyue [1 ,3 ]
机构：
[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China
[2] E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Adv Polymer Mat Shanghai, Shanghai 200237, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
来源：
REACTIVE & FUNCTIONAL POLYMERS | 2011年 / 71卷 / 05期
基金：
高等学校博士学科点专项科研基金;
关键词：
Block copolymer; Micelles; Atom transfer radical polymerization; Thermo-responsive; Poly(N-isopropylacrylamide); CROSS-LINKED MICELLES; TRANSFER RADICAL POLYMERIZATION; BLOCK-COPOLYMERS; TRIBLOCK COPOLYMER; RAFT POLYMERIZATION; HYBRID MICELLES; NANOPARTICLES; RELEASE; FABRICATION; SWELLABILITY;
D O I：
10.1016/j.reactfunctpolym.2011.02.001
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by H-1 NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core-shell-corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies. (c) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：544 / 552
页数：9
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