P38 MITOGEN-ACTIVATED PROTEIN KINASE AND PARKINSON'S DISEASE

被引：43

作者：

He, Jianying ^{[1
,2
,3
]}

Zhong, Wenwen ^{[1
,2
,3
]}

Zhang, Ming ^{[3
]}

Zhang, Rongping ^{[1
,2
]}

Hu, Weiyan ^{[1
,2
,3
,4
]}

机构：

[1] Kunming Med Univ, Sch Pharmaceut Sci, Kunming, Yunnan, Peoples R China

[2] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming, Yunnan, Peoples R China

[3] Kunming Med Univ, Inst Mol & Clin Med, Key Lab Stem Cell & Regenerat Med, Kunming, Yunnan, Peoples R China

[4] Monash Univ, Dept Anat & Dev Biol, Monash Immune Regenerat & Neurosci Labs, Melbourne, Vic, Australia

来源：

TRANSLATIONAL NEUROSCIENCE | 2018年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; p38MAPK; neuro-inflammation; oxidative stress; mitochondrial dysfunction; INDUCED DOPAMINERGIC NEURODEGENERATION; NF-KAPPA-B; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN; ANIMAL-MODELS; MOUSE MODEL; MAPK; MPTP;

D O I：

10.1515/tnsci-2018-0022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson's disease are not fully understood, considerable evidence suggests that neuro-inflammation, oxidative stress, mitochondrial dysfunction, cell proliferation, differentiation and apoptosis are involved in the disease. p38MAPK, an important member of the mitogen-activated protein family, controls several important functions in the cell, suggesting a potential pathogenic role in PD. This review provides a brief description of the role and mechanism of p38MAPK in Parkinson's disease.

引用

页码：147 / 153

页数：7

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