Cross-Reactive Epitopes in Borrelia burgdorferi p66

被引：17
作者：
Arnaboldi, Paul M. [1 ]
Dattwyler, Raymond J.
机构：
[1] Biopeptides Corp, New York, NY 11733 USA
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2015年 / 22卷 / 07期
关键词：
LYME-DISEASE; SERODIAGNOSIS; RECOGNITION; PROTEINS;
D O I：
10.1128/CVI.00217-15
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epitope mapping of the p66 outer membrane protein of Borrelia burgdorferi revealed that the protein contains numerous cross-reactive linear epitopes recognized by serum antibody in the majority of individuals tested, regardless of Lyme disease history, limiting the usefulness of this antigen in Lyme disease serodiagnostic assays.
引用
收藏
页码：840 / 843
页数：4
相关论文
共 13 条
[1]  
[Anonymous], 1995, Morbid.Mortal.Weekly Rep, V44, P590
[2]   Decorin Binding Proteins A and B in the Serodiagnosis of Lyme Disease in North America [J].
Arnaboldi, Paul M. ;
Sambir, Mariya ;
Dattwyler, Raymond J. .
CLINICAL AND VACCINE IMMUNOLOGY, 2014, 21 (10) :1426-1436
[3]   Outer Surface Protein C Peptide Derived from Borrelia burgdorferi Sensu Stricto as a Target for Serodiagnosis of Early Lyme Disease [J].
Arnaboldi, Paul M. ;
Seedarnee, Rudra ;
Sambir, Mariya ;
Callister, Steven M. ;
Imparato, Josephine A. ;
Dattwyler, Raymond J. .
CLINICAL AND VACCINE IMMUNOLOGY, 2013, 20 (04) :474-481
[4]   A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi [J].
Barbour, Alan G. ;
Jasinskas, Algimantas ;
Kayala, Matthew A. ;
Davies, D. Huw ;
Steere, Allen C. ;
Baldi, Pierre ;
Felgner, Philip L. .
INFECTION AND IMMUNITY, 2008, 76 (08) :3374-3389
[5]   P66 porins are present in both Lyme disease and relapsing fever spirochetes: A comparison of the biophysical properties of P66 porins from six Borrelia species [J].
Barcena-Uribarri, Ivan ;
Thein, Marcus ;
Sacher, Anna ;
Bunikis, Ignas ;
Bonde, Mari ;
Bergstrom, Sven ;
Benz, Roland .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2010, 1798 (06) :1197-1203
[6]   Anti-Borrelia burgdorferi Antibody Profile in Post-Lyme Disease Syndrome [J].
Chandra, Abhishek ;
Wormser, Gary P. ;
Marques, Adriana R. ;
Latov, Norman ;
Alaedini, Armin .
CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (05) :767-771
[7]   Regulation of expression of the Borrelia burgdorferi β3-chain integrin ligand, P66, in ticks and in culture [J].
Cugini, C ;
Medrano, M ;
Schwan, TG ;
Coburn, J .
INFECTION AND IMMUNITY, 2003, 71 (02) :1001-1007
[8]   Delineation of Borrelia burgdorferi p66 sequences required for integrin αIIbβ3 recognition [J].
Defoe, G ;
Coburn, J .
INFECTION AND IMMUNITY, 2001, 69 (05) :3455-3459
[9]   Diagnostic value of proteins of three Borrelia species (Borrelia burgdorferi sensu lato) and implications for development and use of recombinant antigens for serodiagnosis of Lyme borreliosis in Europe [J].
Hauser, U ;
Lehnert, G ;
Wilske, B .
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1998, 5 (04) :456-462
[10]   Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi VlsE [J].
Liang, FT ;
Steere, AC ;
Marques, AR ;
Johnson, BJB ;
Miller, JN ;
Philipp, MT .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (12) :3990-3996
12