Application of newly developed globular-shaped granules of beta-tricalcium phosphate for bone substitute

被引：4

作者：

Gonda, Yoshinori ^{[1
,2
]}

Ioku, Koji ^{[3
]}

Okuda, Takatoshi ^{[2
]}

Kawachi, Giichiro ^{[4
]}

Yonezawa, Ikuho

Kurosawa, Hisashi ^{[2
]}

Ikeda, Tohru ^{[1
,2
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Dev & Reconstruct Med, Div Oral Pathol & Bone Metab, 1-7-1 Sakamoto, Nagasaki 8528588, Japan

[2] Juntendo Univ, Sch Med, Dept Orthopaed Surg, Tokyo, 1138421, Japan

[3] Tohoku Univ, Grad Sch Environm Sttudies, Sendai, Miyagi 980, Japan

[4] Nagoya Univ, Grad Sch Engn, Dept Crystalline Mat Sci, Nagoya, Aichi 4648603, Japan

来源：

BIOCERAMICS, VOL 20, PTS 1 AND 2 | 2008年 / 361-363卷

关键词：

beta tricalcium phosphate; bioceramics; bone graft;

D O I：

10.4028/www.scientific.net/KEM.361-363.1013

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Globular-shaped beta-tricalcium phosphate (beta-TCP) granules were synthesized using a unique dropping slurry method and the biological response was analyzed by implantation into the rat femur. Two kinds of globular-shaped beta-TCP granules, composed of either rod-shaped particles or conventional non-rod-shaped particles were synthesized, implanted into the left femurs of 8-week-old female Wistar rats, and analyzed histologically Commercially available beta-TCP granules composed of conventional non-rod-shaped particles were also implanted as a control experiment. Four weeks after the operation, part of each implant was already resorbed and the resorbed area was replaced by newly formed bone tissue and bone marrow. Eight weeks after the operation, the resorption and replacement were advanced in each implant. At 12 weeks after the operation, residual globular-shaped beta-TCP granules composed of rod-shaped particles were resorbed into compact petrotic bone tissue almost completely. The formation of less compact petrotic bone tissue was observed in specimens implanted with globular-shaped beta-TCP granules composed of conventional non-rod-shaped particles. Commercially available beta-TCP granules composed of conventional non-rod-shaped particles were mostly resorbed into trabecular bone and the formation of compact petrotic bone tissue was rarely observed. These data suggested that both the unique spherical shape and microstructurre of beta-TCP particles affected bone-forming activity after the operation.

引用

页码：1013 / +

页数：2

共 4 条

[1] Hydrothermal preparation of tailored hydroxyapatite [J].

Ioku, K ;

Kawachi, G ;

Sasaki, S ;

Fujimori, H ;

Goto, S .

JOURNAL OF MATERIALS SCIENCE, 2006, 41 (05) :1341-1344

[2]

IOKU K, 2004, ARCH BIOCERAM RES, V4, P121

[3] The effect of the microstructure of β-tricalcium phosphate on the metabolism of subsequently formed bone tissue [J].

Okuda, Takatoshi ;

Ioku, Koji ;

Yonezawa, Ikuho ;

Minagi, Hideyuki ;

Kawachi, Giichiro ;

Gonda, Yoshinori ;

Murayama, Hisashi ;

Shibata, Yasuaki ;

Minami, Soichiro ;

Kamihira, Shimeru ;

Kurosawa, Hisashi ;

Ikeda, Tohru .

BIOMATERIALS, 2007, 28 (16) :2612-2621

[4] Influence of surface microstructure on the reaction of the active ceramics in vivo [J].

Yokozeki, H ;

Hayashi, T ;

Nakagawa, T ;

Kurosawa, H ;

Shibuya, K ;

Ioku, K .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1998, 9 (07) :381-384

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