Graphene Biodevices for Early Disease Diagnosis Based on Biomarker Detection

被引：55

作者：

Han, Qingfang ^{[1
,2
]}

Pang, Jinbo ^{[1
]}

Li, Yufen ^{[1
]}

Sun, Baojun ^{[1
,2
]}

Ibarlucea, Bergoi ^{[3
,4
]}

Liu, Xiaoyan ^{[1
]}

Gemming, Thomas ^{[5
]}

Cheng, Qilin ^{[1
]}

Zhang, Shu ^{[1
]}

Liu, Hong ^{[1
,6
]}

Wang, Jingang ^{[1
]}

Zhou, Weijia ^{[1
]}

Cuniberti, Gianaurelio ^{[3
,4
,7
,8
,9
]}

Rummeli, Mark H. ^{[5
,10
,11
,12
,13
]}

机构：

[1] Univ Jinan, Collaborat Innovat Ctr Technol & Equipment Biol D, Inst Adv Interdisciplinary Res iAIR, Jinan 250022, Shandong, Peoples R China

[2] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China

[3] Tech Univ Dresden, Dresden Ctr Computat Mat Sci, D-01062 Dresden, Germany

[4] Tech Univ Dresden, Dresden Ctr Intelligent Mat GCL DCIM, D-01062 Dresden, Germany

[5] Leibniz Inst Solid State & Mat Res Dresden, D-01171 Dresden, Germany

[6] Shandong Univ, Ctr Bio & Micro Nano Funct Mat, State Key Lab Crystal Mat, Jinan 250100, Shandong, Peoples R China

[7] Tech Univ Dresden, Inst Mat Sci, D-01069 Dresden, Germany

[8] Tech Univ Dresden, Max Bergmann Ctr Biomat, D-01069 Dresden, Germany

[9] Tech Univ Dresden, Ctr Adv Elect Dresden, D-01069 Dresden, Germany

[10] Soochow Univ, Coll Energy, Inst Energy & Mat Innovat, Suzhou 215006, Peoples R China

[11] Soochow Univ, Key Lab Adv Carbon Mat & Wearable Energy Technol, Suzhou 215006, Peoples R China

[12] Polish Acad Sci, Ctr Polymer & Carbon Mat, PL-41819 Zabrze, Poland

[13] VSB Tech Univ Ostrava, Inst Environm Technol CEET, 17 Listopadu 15, Ostrava 70833, Czech Republic

来源：

ACS SENSORS | 2021年 / 6卷 / 11期

基金：

中国国家自然科学基金;

关键词：

biodevices; early diagnosis; biomarker detection; graphene; functionalization; field-effect transistors; electrochemical biosensors; optical biosensors; microfluidic system; circulating tumor cells; HIGHLY SENSITIVE DETECTION; DIFFERENTIAL-PULSE VOLTAMMETRY; SINGLE-CRYSTAL GRAPHENE; LABEL-FREE DETECTION; REAL-TIME DETECTION; PI-PI STACKING; QUANTUM DOTS; ELECTROCHEMICAL IMMUNOSENSOR; ULTRASENSITIVE DETECTION; GOLD NANOPARTICLES;

D O I：

10.1021/acssensors.1c01172

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The early diagnosis of diseases plays a vital role in healthcare and the extension of human life. Graphene-based biosensors have boosted the early diagnosis of diseases by detecting and monitoring related biomarkers, providing a better understanding of various physiological and pathological processes. They have generated tremendous interest, made significant advances, and offered promising application prospects. In this paper, we discuss the background of graphene and biosensors, including the properties and functionalization of graphene and biosensors. Second, the significant technologies adopted by biosensors are discussed, such as field-effect transistors and electrochemical and optical methods. Subsequently, we highlight biosensors for detecting various biomarkers, including ions, small molecules, macromolecules, viruses, bacteria, and living human cells. Finally, the opportunities and challenges of graphene-based biosensors and related broad research interests are discussed.

引用

页码：3841 / 3881

页数：41

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