Compound BCR-ABL1 Kinase Domain Mutants: Prevalence, Spectrum and Correlation with Tyrosine Kinase Inhibitor Resistance in a Prospective Series of Philadelphia Chromosome-Positive Leukemia Patients Analyzed By Next Generation Sequencing

被引：3

作者：

Soverini, Simona ^{[1
]}

Bavaro, Luana ^{[1
]}

Martelli, Margherita ^{[1
]}

De Benedittis, Caterina ^{[1
]}

Iurlo, Alessandra ^{[2
]}

Orofino, Nicola ^{[3
]}

Pagano, Livio ^{[4
]}

Criscuolo, Marianna ^{[4
]}

Bonifacio, Massimiliano ^{[5
]}

Scaffidi, Luigi ^{[6
]}

Sica, Simona ^{[7
]}

Sora, Federica ^{[8
]}

Maino, Elena ^{[9
]}

Rondoni, Michela ^{[10
]}

Laginestra, Maria Antonella ^{[11
]}

Lunghi, Francesca ^{[12
]}

Ermacora, Anna ^{[13
]}

D'adda, Mariella ^{[14
]}

Gugliotta, Gabriele ^{[15
]}

Castagnetti, Fausto ^{[16
]}

Rosti, Gianantonio ^{[15
]}

Papayannidis, Cristina ^{[17
]}

Marconi, Giovanni ^{[17
]}

Curti, Antonio ^{[1
]}

Miggiano, Maria Cristina ^{[18
]}

Galimberti, Sara ^{[19
]}

Percesepe, Antonio ^{[20
]}

Stagno, Fabio ^{[21
]}

Sancetta, Rosaria ^{[22
]}

Annunziata, Mario ^{[23
]}

Falzetti, Franca ^{[24
]}

Capodanno, Isabella ^{[25
]}

Pregno, Patrizia ^{[26
]}

Maffioli, Margherita ^{[27
]}

Intermesoli, Tamara ^{[28
]}

Di Bona, Eros ^{[29
]}

Caocci, Giovanni ^{[30
]}

Attolico, Imma ^{[31
]}

Binotto, Gianni ^{[32
]}

Bocchia, Monica ^{[33
]}

Angelucci, Emanuele ^{[34
]}

Sgherza, Nicola ^{[35
]}

Luciano, Luigiana ^{[36
]}

Mignone, Flavio ^{[37
]}

Pileri, Stefano A. ^{[38
]}

Martinelli, Giovanni ^{[39
]}

Cavo, Michele ^{[1
]}

机构：

[1] Univ Bologna, Hematol Oncol L&A Seragnoli, Bologna, Italy

[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Hematol Div, Milan, Italy

[3] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Hematol Unit, Milan, Italy

[4] Univ Cattolica S Cuore, IRCCS, Fdn Policlin A Gemelli, Inst Hematol, Rome, Italy

[5] Univ Verona, Sect Haematol, Dept Med, Verona, Italy

[6] Univ Verona, Sect Hematol, Dept Med, Verona, Italy

[7] Univ Cattolica Sacro Cuore, IRCCS, Fdn Policlin Univ A Gemelli, Hematol Dept, Rome, Italy

[8] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCSS, Rome, Italy

[9] Osped Angelo, Hematol, Venice, Italy

[10] Azienda Unita Sanit Locale Romagna, Haematol Dept, Ravenna, Italy

[11] Dept Expt Diagnost & Specialty Med, Hematopathol Sect, Bologna, Italy

[12] Ist Sci San Raffaele, IRCCS, Haematol & Bone Marrow Transplant Unit, Milan, Italy

[13] Azienda Ospedaliera S Maria Angeli, Pordenone, Italy

[14] ASST Spedali Civili Brescia, Dept Hematol, Brescia, Italy

[15] Inst Hematol L&A Seragnoli, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[16] Univ Bologna, DIMES, Inst Hematol L&A Seragnoli, Bologna, Italy

[17] Univ Bologna, Inst Hematol L&A Seragnoli, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[18] Hematol Unit, Vicenza, Italy

[19] Univ Pisa, Dept Clin & Expt Med, Sect Hematol, Pisa, Italy

[20] Univ Parma, Med Genet Unit, Dept Med & Surg, Parma, Italy

[21] Univ Catania, Ferrarotto Hosp, Hematol Unit, Catania, Italy

[22] Osped Angelo Mestre, Hematol Unit, Venice, Italy

[23] Osped Cardarelli, Hematol, Naples, Italy

[24] Univ Perugia, CREO, Inst Hematol, Perugia, Italy

[25] Arcispedale Santa Maria Nuova IRCCS Reggio, Hematol Dept, Reggio Emilia, Italy

[26] Az Osped Univ Citta Salute & Sci, Hematol Unit, Turin, Italy

[27] Osped Circolo Varese, ASST Sette Laghi, Dept Med & Surg, Hematol, Varese, Italy

[28] ASST Papa Giovanni XXIII, Hematol & Bone Marrow Transplantat Unit, Bergamo, Italy

[29] UO Hematol, Osped San Bortolo, Vicenza, Italy

[30] Univ Cagliari, A Businco Hosp, Dept Med Sci & Publ Hlth, Cagliari, Italy

[31] Univ Bari, Haematol, Potenza, Italy

[32] Padua Sch Med, Dept Med Hematol & Clin Immunol, Padua, Italy

[33] Univ Siena, Azienda Osped Univ, Chair Hematol, Siena, Italy

[34] Osped A Businco, Unita Operat Ematol, Hematol & Transplant Ctr, Genoa, Italy

[35] Osped Casa Sollievo Sofferenza, IRCCS, Div Hematol, San Giovanni Rotondo, Italy

[36] AOU Univ Napoli Federico II, Naples, Italy

[37] Univ Piemonte Orientale, Dept Sci & Innovat Technol DISIT, Alessandria, Italy

[38] European Inst Oncol, Unit Hematopathol, Milan, Italy

[39] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Meldola, Italy

来源：

BLOOD | 2018年 / 132卷

关键词：

D O I：

10.1182/blood-2018-99-117166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

789

引用

页数：6