Mechanisms of the Improvement in Peak VO2 With Exercise Training in Heart Failure With Reduced or Preserved Ejection Fraction

被引：59

作者：

Tucker, Wesley J. ^{[1
]}

Lijauco, Cecilia C. ^{[1
]}

Hearon, Christopher M., Jr. ^{[2
,3
]}

Angadi, Siddhartha S. ^{[4
,5
]}

Nelson, Michael D. ^{[1
]}

Sarma, Satyam ^{[2
,3
]}

Nanayakkara, Shane ^{[6
,7
]}

La Gerche, Andre ^{[8
,9
]}

Haykowsky, Mark J. ^{[1
,10
]}

机构：

[1] Univ Texas Arlington, Coll Nursing & Hlth Innovat, 411 S Nedderman Dr, Arlington, TX 76010 USA

[2] Texas Hlth Presbyterian Hosp, Inst Exercise & Environm Med, Dallas, TX USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA

[4] Arizona State Univ, Exercise Sci & Hlth Promot Program, Phoenix, AZ USA

[5] Mayo Clin, Div Cardiovasc Dis, Scottsdale, AZ USA

[6] Baker Heart & Diabet Res Inst, Heart Failure Res Grp, Melbourne, Vic, Australia

[7] Monash Univ, Melbourne, Vic, Australia

[8] Baker Heart & Diabet Res Inst, Sport Cardiol, Melbourne, Vic, Australia

[9] Univ Leuven, Dept Cardiovasc Med, Leuven, Belgium

[10] Alfred Hosp, Dept Cardiovasc Med, Melbourne, Vic, Australia

来源：

HEART LUNG AND CIRCULATION | 2018年 / 27卷 / 01期

关键词：

Heart failure; Exercise training; Aerobic capacity; Cardiac function; Vascular function; Skeletal muscle function; LEFT-VENTRICULAR FUNCTION; QUALITY-OF-LIFE; SINGLE-BLIND TRIAL; SKELETAL-MUSCLE; OLDER PATIENTS; CARDIOVASCULAR-RESPONSES; ENDOTHELIAL DYSFUNCTION; CARDIAC REHABILITATION; FUNCTIONAL-CAPACITY; ARTERIAL STIFFNESS;

D O I：

10.1016/j.hlc.2017.07.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure (HF) is a major health care burden associated with high morbidity and mortality. Approximately 50% of HF patients have reduced ejection fraction (HFrEF) while the remainder of patients have preserved ejection fraction (HFpEF). A hallmark of both HF phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary to impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training is a safe and effective intervention to improve peak oxygen uptake (VO2peak) and quality of life in clinically stable HF patients, however, evidence to date suggests that the mechanism of this improvement appears to be related to underlying HF phenotype. The purpose of this review is to discuss the role of exercise training to improve VO2peak, and how the central and peripheral adaptations that mediate the improvements in exercise tolerance may be similar or differ by HF phenotype (HFrEF or HFpEF).

引用

页码：9 / 21

页数：13

共 71 条

[1] Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction [J].